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| | 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Basic information |
| Product Name: | 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE | | Synonyms: | APOPTOSIS ACTIVATOR 2;APOPTOSIS ACTIVATOR II;1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-;Apoptosis Activator 2, >=98%;Apoptosis Activator 2, 97%, a cytochrome c caspase activator and apoptosis inducer;CS-572 | | CAS: | 79183-19-0 | | MF: | C15H9Cl2NO2 | | MW: | 306.14 | | EINECS: | 200-256-5 | | Product Categories: | Inhibitors;Caspases/Apoptosis | | Mol File: | 79183-19-0.mol |  |
| | 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Chemical Properties |
| Boiling point | 470.6±55.0 °C(Predicted) | | density | 1.494 | | Fp | 238.4℃ | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | Soluble in DMSO | | form | Orange to red solid. | | pka | -2.69±0.20(Predicted) | | Sensitive | Light Sensitive |
| Safety Statements | 24/25 | | RIDADR | 3077 | | HS Code | 29145090 |
| | 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Usage And Synthesis |
| Uses | Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines | | Uses | Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells. | | Definition | ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles. | | Biological Activity | Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M). | | storage | Room temperature | | references | [1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22. |
| | 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Preparation Products And Raw materials |
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