| Description | Methyl n-methylanthranilate has an orange and mandarin peel-like
odor with a musty, grape-like flavor. It is somewhat more berry-like than grape. May be prepared by methylation of methyl anthranilate or esterification of N-methylanthranilic acid. |
| Chemical Properties | Methyl-n-methylanthranilate has an orange and mandarin peel-like odor and a musty, grape-like flavor; somewhat
more berry-like than grape. |
| Chemical Properties | Methyl N-Methylanthranilate is the main
component of petitgrain oils from mandarin leaves and is also found in mandarin
oil. It is a pale yellow, fluorescent liquid with a delicate mandarin odor. The ester
can be prepared by methylation ofmethyl anthranilate. It is used in soap and cosmetic
perfumes as well as in aromas, particularly for mandarin flavors. |
| Occurrence | Reported found in mandarin essential oil and mandarin leaves essential oil (50 to 76.5%); also reported in the
oil from bulbs of Kaempferia ethelae L., in orange petitgrain, and in the oil from hyacinth flowers. Also reported found in starfruit,
orange peel oil and grapefruit juice. |
| Uses | It is
used as a flavorant in a wide range of foods (particularly flour
and sugar confections). |
| Uses | Methyl 2-(Methylamino)benzoate is one of many volatile components from mango cultivars. |
| Definition | ChEBI: Methyl N-methylanthranilate is a methyl ester resulting from the formal condensation of the carboxy group of N-methylanthranilic acid with methanol. It has a role as a fungal metabolite, a plant metabolite and an animal metabolite. It is a benzoate ester, a methyl ester, a secondary amino compound and a substituted aniline. It is functionally related to a N-methylanthranilic acid. |
| Preparation | By methylation of methyl anthranilate or esterification of N-methylanthranillic acid. |
| Production Methods | Methyl N-methanthranilate is a component of mandarin and
mandarin tree leaf essential oil. It is also found in oil from
bulbs of Kaempferia ethelae L., hyacinth flowers, and orange
petitgrain . It is synthesized by methylation of methyl
anthranilate or esterification ofN-methylanthranilic acid. |
| Taste threshold values | Taste characteristics at 10 ppm: fruity grape skin, anthranilate-like with a woody and floral nuance |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 49, p. 3373, 1984 DOI: 10.1021/jo00192a024 |
| Toxicity evaluation | The acute oral LD50 value in rats was reported as 3.7 ml/kg (Levenstein, 1974). The acute oral LD50 in female rats was reported to be between 2.25 g/kg (no deaths) and 3.38 g/kg (100% deaths) (Gaunt, Sharratt, Grasso & Wright, 1970). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Levenstein, 1974). The LC 50 for larvae of Tribolium destructor was found to be 0-1151 mg/cm3 (Vasechko, Kuznetsov, Smelyanets & Guznenok, 1970). |
| Safety Profile | Poison by intravenous
route. Moderately toxic by ingestion.
Combustible liquid. When heated to
decomposition it emits toxic fumes of NOx.
See also ESTERS. |
