1,2-Bis(chloromethyl)benzene

1,2-Bis(chloromethyl)benzene Basic information
Product Name:1,2-Bis(chloromethyl)benzene
Synonyms:DICHLORO(ALPHA, ALPHA'-)-O-XYLENE;O-XYLYLENE CHLORIDE;O-XYLYLENE DICHLORIDE;A,A'-DICHLORO-O-XYLENE;A,A-DICHLORO-O-XYLENE;ALPHA,ALPHA'-DICHLORO-O-XYLENE;1,2-BIS(CHLOROMETHYL)BENZENE;1,2-DI(CHLOROMETHYL)BENZENE
CAS:612-12-4
MF:C8H8Cl2
MW:175.06
EINECS:210-291-8
Product Categories:Pharmaceutical Intermediates;Aryl;Building Blocks;C8;Chemical Synthesis;Halogenated Hydrocarbons;Organic Building Blocks
Mol File:612-12-4.mol
1,2-Bis(chloromethyl)benzene Structure
1,2-Bis(chloromethyl)benzene Chemical Properties
Melting point 51-55 °C (lit.)
Boiling point 239-241 °C (lit.)
density 1.3930
refractive index 1.5544 (estimate)
Fp 226 °F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility soluble in Methanol
form Crystals or Crystalline Powder
color white to light beige
Water Solubility hydrolysis
BRN 2043675
CAS DataBase Reference612-12-4(CAS DataBase Reference)
NIST Chemistry ReferenceBenzene, 1,2-bis(chloromethyl)-(612-12-4)
EPA Substance Registry System1,2-Bis(chloromethyl)benzene (612-12-4)
Safety Information
Hazard Codes C,Xi
Risk Statements 34-36/37-36/37/38-50/53-26-22-36
Safety Statements 26-27-28-36/37/39-45-24/25-61-29-28A
RIDADR UN 3261 8/PG 2
WGK Germany 2
RTECS ZE4085000
19
TSCA Yes
HazardClass 6.1
PackingGroup II
HS Code 29036990
MSDS Information
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1,2-Bis(chloromethyl)benzene Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powde
Uses1,2-Bis(chloromethyl)benzene is used in solid-phase synthesis of large combinatorial variations of fundamental peptide unit 1 .
Usesα,α′?Dichloro-o-xylene was used in solid-phase synthesis of large combinatorial variations of fundamental peptide unit.
General Descriptionα,α′-Dichloro-o-xylene reacts with elemental tellurium and NaI in 2-methoxyethanol to form 1,1-diiodo-3,4-benzo-1-telluracyclopentane.
Safety ProfilePoison by intravenous route. Mutation data reported. See also CHLORINATED HYDROCARBONS, AROMATIC. When heated to decomposition it emits toxic Cl-.
1,2-Bis(chloromethyl)benzene Preparation Products And Raw materials
Preparation ProductsBenzene, 1,1'-methylenebis[4-(chloromethyl)--->1,2-BIS(DIPHENYLPHOSPHINOMETHYL)BENZENE-->2-BENZYL-2,3-DIHYDRO-1H-ISOINDOLE-->Phthalan
m-Bis(chloromethyl)benzene,ALPHA,ALPHA''-DICHLORO-M-XYLENE / 1,3-BIS(CHLOROMETHYL)BENZENE,1,3-BIS(CHLOROMETHYL)BENZENE BENZAL CHLORIDE Benzyl chloride Chloromethyl methyl ether 2-Aminobenzylchloride alpha-Chloro-o-fluorotoluene Musk xylene 2,4-Dichlorobenzyl alcohol 2-Methylbenzyl chloride Benzene 1,2-Dichloro-4-(chloromethyl)benzene 2,3-Dichlorobenzyl chloride Cobalt chloride Dichloroethane 2-(Chloromethyl)benzonitrile Thionyl chloride 2,4-Dichlorobenzyl chloride Diethylstilbestrol

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