METHYL 2,5-DIHYDROXYCINNAMATE

METHYL 2,5-DIHYDROXYCINNAMATE Basic information
Product Name:METHYL 2,5-DIHYDROXYCINNAMATE
Synonyms:2,5-DIHYDROXYMETHYLCINNAMATE;2,5-DIHYDROXYCINNAMIC ACID METHYL ESTER;ERBSTATIN ANALOG;ERBSTATIN ANALOGUE;3-(2,5-Dihydroxy-phenyl)-acrylicacidmethylester;METHYL 2,5-DIHYDROXYCINNAMATE;Erbstatin analog, Methyl 2,5-dihydroxycinnamate;Methyl 2,5-dihyroxycinnamate
CAS:63177-57-1
MF:C10H10O4
MW:194.18
EINECS:
Product Categories:Aromatic Cinnamic Acids, Esters and Derivatives;All Inhibitors;Inhibitors;Tyrosine Kinase Inhibitors
Mol File:63177-57-1.mol
METHYL 2,5-DIHYDROXYCINNAMATE Structure
METHYL 2,5-DIHYDROXYCINNAMATE Chemical Properties
Melting point 178-180°C
density 1.318±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 0.1 M NaOH: soluble
form crystalline
color yellow
Water Solubility Soluble in methanol or 0.1M NaOH. Insoluble in water
CAS DataBase Reference63177-57-1(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 23/24/25-36/37/38
Safety Statements 22-26-36-45
WGK Germany 3
HS Code 2918.29.7500
HazardClass 6.1
MSDS Information
ProviderLanguage
SigmaAldrich English
METHYL 2,5-DIHYDROXYCINNAMATE Usage And Synthesis
Chemical PropertiesYellow-Brown Crystalline Powder
UsesAn inhibitor of the EGF receptor associated tyrosine kinase
UsesA stable Erbstatin analogue that inhibits tyrosine kinase. Shown to delay the S-phase induction by epidermal growth factor in quiescent normal rat kidney cells, without affecting the total amount of DNA synthesis
DefinitionChEBI: 2,5-dihydroxycinnamic acid methyl ester is a cinnamate ester that is the methyl ester of 2,5-dihydroxycinnamic acid. It has a role as a human urinary metabolite, a plant metabolite, a geroprotector and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a cinnamate ester, a member of hydroquinones and a methyl ester.
METHYL 2,5-DIHYDROXYCINNAMATE Preparation Products And Raw materials
Canertinib TYRPHOSTIN A25 AG 825 H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH METHYL 2,5-DIHYDROXYCINNAMATE METHYL 3,4-DIHYDROXYCINNAMATE AURORA 6677 3-PYRIDINYLMETHYL 6-METHOXY-2H-CHROMENE-3-CARBOXYLATE PHENETHYL 6-METHOXY-2H-CHROMENE-3-CARBOXYLATE 2,5-DIHYDROXYCINNAMIC ACID AURORA 6682 Methyl cinnamate 6-METHOXY-2H-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER 4-METHOXYBENZYL 6-METHOXY-2H-CHROMENE-3-CARBOXYLATE AURORA 5701 AURORA 6678 AURORA 6680 6-METHOXY-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER

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