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Butyl chloroformate

Butyl chloroformate Basic information
Product Name:Butyl chloroformate
Synonyms:N-BUTYL CHLOROFORMATE;Butoxycarbonyl chloride;Butyl chloridocarbonate;Butyl chlorocarbonate;carbonochloridicacid,butylester;carbonochloridicacidbutylester;Formic acid, chloro-, butyl ester;BUTYL CHLOROCARBOXYLATE
CAS:592-34-7
MF:C5H9ClO2
MW:136.58
EINECS:209-750-5
Product Categories:Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Acid Halides;Carbonyl Compounds;Organic Building Blocks;Pharmaceutical Intermediates;CHLOROFORMATES;bc0001
Mol File:592-34-7.mol
Butyl chloroformate Structure
Butyl chloroformate Chemical Properties
Melting point -70 °C
Boiling point 142 °C(lit.)
density 1.074 g/mL at 25 °C(lit.)
vapor pressure 2.42 psi ( 20 °C)
refractive index n20/D 1.412(lit.)
Fp 77 °F
storage temp. 2-8°C
form Liquid
color Clear
Water Solubility DECOMPOSES
Sensitive Moisture Sensitive
BRN 605635
LogP1.895 (est)
CAS DataBase Reference592-34-7(CAS DataBase Reference)
NIST Chemistry ReferenceCarbonochloridic acid, butyl ester(592-34-7)
EPA Substance Registry Systemn-Butyl chloroformate (592-34-7)
Safety Information
Hazard Codes T
Risk Statements 10-23-34
Safety Statements 26-36-45
RIDADR UN 2743 6.1/PG 2
WGK Germany 1
F 10-19
TSCA Yes
HazardClass 6.1
PackingGroup I
HS Code 29159020
MSDS Information
ProviderLanguage
Butyl chloroformate English
SigmaAldrich English
ACROS English
ALFA English
Butyl chloroformate Usage And Synthesis
Chemical Propertiesclear liquid
UsesButyl Chloroformate is a reactant in the preparation of Lapatinib derivatives as HER1/HER2 targeting antitumor drugs.
General DescriptionA colorless liquid. Flash point near 70°F. Very toxic by inhalation. Denser than water. Used to make other chemicals.
Air & Water ReactionsHighly flammable. Decomposes exothermically in water to give hydrochloric acid and organic acids.
Reactivity ProfileButyl chloroformate is incompatible with bases (including amines), with water, with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health HazardInhalation of vapor irritates nose and throat and can cause delayed pulmonary edema. Liquid irritates eyes and causes severe skin burns and irreversible skin damage if allowed to remain. Can cause blindness. Ingestion causes burns of mouth and stomach.
Flammability and ExplosibilityFlammable
Butyl chloroformate Preparation Products And Raw materials
Raw materialsDIBUTYL CARBONATE-->1-Butanol-->Triphosgene-->Chloroform-->Diphosgene-->PHOSGENE
Preparation Products1-Chlorobutane-->Butyl formate-->O-butyl carbonisothiocyanatidate
CHLOROFORMIC ACID N-OCTYL ESTER 5A-CHOLESTAN-3B-YL CHLOROFORMATE 2-Ethylhexyl chloroformate t-butyl chloroformate Cyhalofop-butyl 1,4-BUTANEDIOL BIS(CHLOROFORMATE) 4-tert-Butylcyclohexyl chloroformate Lauryl chloroformate Buprofezin DIBUTYL ISOPHTHALATE Cetyl chloroformate Heptyl chloroformate BUTYL OLEATE SEC-BUTYL CHLOROFORMATE Myristyl chloroformate Chloroformate Cholesteryl chloroformate Pentyl chloroformate
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