N-Benzyloxycarbonyl-L-asparagine

N-Benzyloxycarbonyl-L-asparagine Basic information
Product Name:N-Benzyloxycarbonyl-L-asparagine
Synonyms:n2-[(phenylmethoxy)carbonyl]-l-asparagin;L-Asparagine, N-CBZ protected;N-α-Z-L-asparagine;N(a)-Benzyloxycarbonyl-L-asparagine;N-A-CBZ-L-ASPARAGINE CRYSTALLINE;N2-[(PHENYLMEHTOXY)CARBONYL]-L-ASPARAGINE;CBZ-L-Asparagine-OH;N(alpha)-Benzyloxycarbonyl-L-asparagine~Z-Asn-OH
CAS:2304-96-3
MF:C12H14N2O5
MW:266.25
EINECS:218-969-5
Product Categories:Z-Amino acid series;Chiral Compounds;Amino Acids;Amino Acids (N-Protected);Biochemistry;Cbz-Amino Acids;chiral;Amino Acid Derivatives;PROTECTED AMINO ACID & PEPTIDES;Asparagine [Asn, N];Z-Amino Acids and Derivatives;Alkyl;Asparagine;Building Blocks;Chemical Biology;Chemical Synthesis;Halogenated Hydrocarbons;Organic Building Blocks;Peptide Chemistry
Mol File:2304-96-3.mol
N-Benzyloxycarbonyl-L-asparagine Structure
N-Benzyloxycarbonyl-L-asparagine Chemical Properties
Melting point 163-165 °C(lit.)
alpha 6.5 º (c=2, CH3COOH)
Boiling point 409.45°C (rough estimate)
density 1.2846 (rough estimate)
refractive index 6.3 ° (C=1.6, AcOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility almost transparency in hot Methanol
pka3.77±0.10(Predicted)
form powder to crystal
color White to Almost white
optical activity[α]20/D +6°, c = 1.6 in acetic acid
BRN 3085452
InChIKeyFUCKRCGERFLLHP-VIFPVBQESA-N
CAS DataBase Reference2304-96-3(CAS DataBase Reference)
EPA Substance Registry SystemL-Asparagine, N2-[(phenylmethoxy)carbonyl]- (2304-96-3)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 24/25-36-26
WGK Germany 3
TSCA Yes
HazardClass IRRITANT
HS Code 29242990
MSDS Information
ProviderLanguage
4-Amino-2-{[(benzyloxy)carbonyl]amino}-4-oxobutanoic acid English
ACROS English
SigmaAldrich English
ALFA English
N-Benzyloxycarbonyl-L-asparagine Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powde
UsesNα-Cbz-L-asparagine is an N-Cbz-protected form of L-Asparagine (A790005). L-Asparagine was first isolated by Robiquet and Vauquelin from asparagus juice (a high source of L-asparagine). L-Asparagine is often incorporated into proteins, and is a basis for some cancer therapies as certain cancerous cells require L-asparagine for growth.
N-Benzyloxycarbonyl-L-asparagine Preparation Products And Raw materials
Preparation ProductsZ-ASN-GLY-OH-->(S)-3-N-CBZ-AMINO-SUCCINIMIDE -->Z-ASN-ONP
Z-ASN-OTBU 1,1'-Carbonyldiimidazole N-Benzyloxycarbonyl-L-asparagine ASPARAGINASE Trimethoprim Carbonyl iron powder PYRAZOPHOS N-Carbobenzyloxyglycine L-Asparagine D-(-)-Asparagine monohydrate DDZ-ASN-OH CARBONYL SULFIDE 6-Aminocaproic acid Glycine Z-ASN(MTT)-OH FMOC-ASN(TRT)-OPFP tert-Butyl carbazate Diethylstilbestrol

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