Pentoxyverine

Pentoxyverine Basic information

Product Name:	Pentoxyverine
Synonyms:	1-phenyl-1-cyclopentanecarboxylate;1-Phenylcyclopentane-1-Carboxylic acid diethylaminoethoxyethyl ester;1-phenylcyclopentane-1-carboxylicaciddiethylaminoethoxyethylester;1-phenyl-cyclopentanecarboxylicaci2-(2-(diethylamino)ethoxy)ethylester;1-phenylcyclopentanecarboxylicacid2-(2-diethylaminoethoxy)ethylester;ucb2543;CARETAPENTANE;Carbetapentane (base and/or unspecified salts)
CAS:	77-23-6
MF:	C20H31NO3
MW:	333.46
EINECS:	201-014-1
Product Categories:	Miscellaneous Biochemicals
Mol File:	77-23-6.mol

Pentoxyverine Chemical Properties

Boiling point	165-170 °C (1.33Pa)
density	1.048±0.06 g/cm3(Predicted)
refractive index	1.4990-1.5010
storage temp.	Refrigerator
solubility	Dichloromethane (Slightly), Methanol (Slightly)
form	Oil
pka	9.69±0.25(Predicted)
color	Clear Very Dark Red to Brown
CAS DataBase Reference	77-23-6(CAS DataBase Reference)
NIST Chemistry Reference	1-Cyclopentanecarboxylate, 2-(diethylaminoethoxy)ethyl-1-phenyl-(77-23-6)

Safety Information

Hazardous Substances Data	77-23-6(Hazardous Substances Data)
Toxicity	LD50 oral in rat: 150mg/kg

MSDS Information

Provider	Language
2-(2-Diethylaminoethoxy)ethyl 1-phenylcyclopentane-1-carboxylate	English

Pentoxyverine Usage And Synthesis

Originator	Asthma ,Nichiiko
Uses	Carbetapentane is an antitussive anticonvulsant sigma site agonist.
Definition	ChEBI: 1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester is a member of benzenes.
Manufacturing Process	1-Phenylcyclopentane carbonitrile was obtained by treatment of phenylacetonitrile with sodium amide and 1,4-dibrombutane. 1-Phenyl-1-cyclopentane carboxylic acid was produced in the result of reaction of 1-phenylcyclopentane carbonitrile with sulfuric acid. 1-Phenyl-1-cyclopentanecarbonyl chloride was obtained by treatment of 1phenyl-1-cyclopentane carboxylic acid with thionyl chloride. A mixture of 0.5 mol of 1-phenyl-1-cyclopentanecarbonyl chloride and of 0.5 mol of 2-(2-diethylaminoethoxy)ethanol (herein-after referred to as the amino alcohol) in 300 ml of toluene is heated under reflux for 20 h. The mixture is thereafter made alkaline by means of an aqueous solution of caustic soda and decanted; the toluenic layer is washed with water and concentrated in vacuo. The residue is distilled under high vacuum. After two fractional distillations, the 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentane-carboxylate is obtained, in 85% yield. Boiling point 164°C/0.1 mm. Hg.
Brand name	Toclase (Pfizer).
Therapeutic Function	Antitussive

Pentoxyverine Preparation Products And Raw materials

Raw materials

Calcium chloride-->Diethylamine-->Trichloroethylene-->1-Phenylcyclopentanecarboxylic acid-->1,4-Dibromobutane-->phenylacetonitrile-->1-Phenyl-1-cyclopentanecarbonitrile-->α-Phenylcyclopentanecarbonyl chloride-->Sesamol-->6-Ethyl-3-oxa-6-azaoctanol-->Sodium amide-->Thionyl chloride

pentoxifylline-alpha-methoxy-alpha-(trifluoromethyl)phenylacetate ester HYDROXY PENTOXIFYLLINE-D3 PENTOXIFYLLINE-D6 Pentoxifylline BP2000 PENTOXIFYLLINE EPP(CRM STANDARD) Pentoxyverine-d5 citrate 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester PENTOXIFYLLINE IMP. F (EP): CAFFEINE Pentoxifylline(Trental) PENTOXIFYLLINE IMP. A (EP): THEOBROMINE PENTOXYVERINE HYDROGEN CITRATE REFERENCE SPECTRUM EPY(CRM STANDARD) PENTOXYVERINE IMPURITY B 2-(DIETHYLAMINO)ETHYL-1-PHENYLCYCLOPENTANECARBOXYLATE (CARAMIPHEN) EPY(CRM STANDARD) PENTOXIFYLLINE-D3 PENTOXIFYLLINE-4',4',6',6',6',8-D6 PENTOXYVERINE IMPURITY A1-PHENYLCYCLOPENTANECARBOXYLIC ACID EPY(CRM STANDARD) Cyclopentyl chloride PENTOXYVERINE IMPURITY A acetic acid, triethoxy-, ethyl ester

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