Voriconazole (2R,3R)-Isomer

Voriconazole (2R,3R)-Isomer Basic information
Product Name:Voriconazole (2R,3R)-Isomer
Synonyms:Voriconazole (2R,3R)-Isomer;(2R,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol compound with (2S,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1- (1H-1,2,4-triazol-1-yl)butan-2-ol (1:1) ;(αR,βR)-rel-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;4-Pyrimidineethanol, 6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-rel-;Voriconazole 3-Epimer;(αR,?βR)?-?rel-6-?Chloro-?α-?(2,?4-?difluorophenyl)?-?5-?fluoro-?β-?methyl-?α-?(1H-?1,?2,?4-?triazol-?1-?ylmethyl)?-4-?pyrimidineethanol;(2R,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol compound with (2S,3S);Azilsartan medoxomil impurity317
CAS:137234-76-5
MF:C16H13ClF3N5O
MW:383.76
EINECS:
Product Categories:
Mol File:137234-76-5.mol
Voriconazole (2R,3R)-Isomer Structure
Voriconazole (2R,3R)-Isomer Chemical Properties
Boiling point 529.9±60.0 °C(Predicted)
density 1.51±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Dichloromethane (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol
form Solid
pka11.44±0.29(Predicted)
color White to Off-White
Safety Information
MSDS Information
Voriconazole (2R,3R)-Isomer Usage And Synthesis
Uses(αR,?βR)?-?rel-6-?Chloro-?α-?(2,?4-?difluorophenyl)?-?5-?fluoro-?β-?methyl-?α-?(1H-?1,?2,?4-?triazol-?1-?ylmethyl)?-4-?pyrimidineethanol is an intermediate in synthesizing rel-(R,R)-Voriconazole (V759990), The (R,R)-enantiomer of Voriconazole. An antifungal (systemic). An ergosterol biosynthesis inhibitor.
Voriconazole (2R,3R)-Isomer Preparation Products And Raw materials
Voriconazole Vfend 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine rac 5-Desfluoro Voriconazole Voriconazole-13C3 Voriconazole Related CoMpound C (1R)-(-)-10-Camphorsulfonic acid Voriconazole Impurity 53 Voriconazole Voriconazole Impurity 8 Voriconazole Impurity 18 [2H3]- Voriconazole N-Oxide Voriconazole Related CoMpound B 2-Chloro-2',4'-difluoroacetophenone Voriconazole N-Oxide (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone ent-Voriconazole 4-Ethyl-5-fluoro-6-hydroxypyrimidine

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