5-Methoxysalicylic acid

5-Methoxysalicylic acid Basic information
Product Name:5-Methoxysalicylic acid
Synonyms:RARECHEM AL BO 0993;LABOTEST-BB LT00847979;acid5-methoxysalicylic;2-Hydroxy-5-Methoxybenzoic;Benzoic acid, 2-hydroxy-5-methoxy-;2-HYDROXY-5-METHOXYBENZOIC ACID;6-HYDROXY-3-ANISIC ACID;5-O-METHYL GENTISIC ACID
CAS:2612-02-4
MF:C8H8O4
MW:168.15
EINECS:220-037-8
Product Categories:Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Acids and Derivatives;Alcohols and Derivatives;Organic acids;Building Blocks;C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
Mol File:2612-02-4.mol
5-Methoxysalicylic acid Structure
5-Methoxysalicylic acid Chemical Properties
Melting point 141-143 °C(lit.)
Boiling point 217.07°C (rough estimate)
density 1.1816 (rough estimate)
refractive index 1.4611 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka3.01±0.10(Predicted)
form Fine Crystalline Powder
color Beige
Water Solubility 1.7 g/L (10 ºC)
BRN 2209647
InChIKeyIZZIWIAOVZOBLF-UHFFFAOYSA-N
LogP2.100 (est)
CAS DataBase Reference2612-02-4(CAS DataBase Reference)
EPA Substance Registry SystemBenzoic acid, 2-hydroxy-5-methoxy- (2612-02-4)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 26-36
WGK Germany 3
TSCA Yes
HS Code 29189900
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
5-Methoxysalicylic acid Usage And Synthesis
Description5-Methoxysalicylic acid is a chemical compound belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. It is a component of castoreum, the exudate from the castor sacs of the mature beaver.
A mixture of 5-methoxysalicylic acid and spermine can be used as a matrix for oligonucleotides analysis in MALDI mass spectrometry.
It is an isomer of vanillic acid.
2-Hydroxy-5-methoxybenzoic acid is matrix additive which enhances the electrical conductivity of the matrix crystal during matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).
Chemical Propertiesbeige fine crystalline powder
Uses5-Methoxysalicylic acid was used to evaluate MALDI matrix/solvent combinations for intact spore mass spectrometry of Fusarium species.
Uses2-Hydroxy-5-methoxybenzoic acid was used to evaluate MALDI matrix/solvent combinations for intact spore mass spectrometry of Fusarium species.
DefinitionChEBI:5-methoxysalicylic acid is a methoxysalicylic acid that is salicylic acid which is carrying a methoxy group at position 5. It has a role as a bacterial metabolite and a human urinary metabolite.
Synthesis Reference(s)Journal of the American Chemical Society, 72, p. 2301, 1950 DOI: 10.1021/ja01161a530
General Description2-Hydroxy-5-methoxybenzoic acid is matrix additive which enhances the electrical conductivity of the matrix crystal during matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).
5-Methoxysalicylic acid Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Hydrochloric acid-->Sodium bicarbonate-->Carbon tetrachloride-->Copper-->Activated carbon-->4-Methoxyphenol
Preparation ProductsGENTISIN-->5-METHOXYSALICYLAMIDE
2-HYDROXY-5-METHOXY-BENZOIC ACID ETHYL ESTER 5-Methoxysalicylic acid Ethyl 2-(Chlorosulfonyl)acetate 4-Methylsalicylic acid Anisole Folic acid (Trifluoromethoxy)benzene Glycine p-Anisic acid p-Anisidine Methoxyacetic acid p-Anisaldehyde phosphoric acid 2,5-DIMETHOXY-3-NITROBENZOIC ACID CHLOROPHOSPHONAZO III ETHYL 5-ETHOXY-2-HYDROXYBENZOATE 5-Methylsalicylic acid 2,5-Dimethoxybenzoic acid

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