ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards (Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate Basic information
Product Name:(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Synonyms:(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;Nintedanib impurity 12/Methyl (Z)-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;Nintedanib-013-Z;Nidanibu Impurity 8;Nintedanib impurities11;1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(hydroxyphenylmethylene)-2-oxo-, methyl ester, (3Z)-
CAS:2093243-16-2
MF:C17H13NO4
MW:295.29
EINECS:
Product Categories:
Mol File:2093243-16-2.mol
(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate Structure
(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate Chemical Properties
Melting point >215°C (dec.)
Boiling point 536.9±50.0 °C(Predicted)
density 1.357±0.06 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka4.50±1.00(Predicted)
color Yellow to Dark Yellow
Safety Information
MSDS Information
(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate Usage And Synthesis
Uses(Z)-Methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is a useful intermediate for the preparation of nintedanib esylate. Nintedanib is a drug for the treatment of idiopathic pulmonary fibrosis.
(Z)-methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate Preparation Products And Raw materials
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