|
| | Fleroxacin Basic information |
| Product Name: | Fleroxacin | | Synonyms: | AM-833, Ro-23-6240, Megalocin, Megalone, Quinodis, 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid;AM-833, Megalocin, Megalone, 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid, 6,8-Difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)quinoline-3-carboxylic acid;6,8-difluoro-1-(2-fluoroethyl)-4-keto-7-(4-methylpiperazin-1-yl)quinoline-3-carboxylic acid;6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid;6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid;6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid
Megalone | | CAS: | 79660-72-3 | | MF: | C17H18F3N3O3 | | MW: | 369.34 | | EINECS: | 677-525-2 | | Product Categories: | Quinodis, Megalocin;Antibiotics for Research and Experimental Use;Biochemistry;Quinolones (Antibiotics for Research and Experimental Use);Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 79660-72-3.mol |  |
| | Fleroxacin Chemical Properties |
| Melting point | 264-266°C | | Boiling point | 535.3±50.0 °C(Predicted) | | density | 1.409±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | 0.1 M NaOH: soluble10mg/mL | | form | solid | | pka | -0.54±0.20(Predicted) | | color | white to off-white | | Merck | 14,4099 | | CAS DataBase Reference | 79660-72-3(CAS DataBase Reference) |
| WGK Germany | 2 | | RTECS | VB1999050 | | HS Code | 29335990 |
| | Fleroxacin Usage And Synthesis |
| Description | Fleroxacin is a new, once daily trifluoroquinolone antibacterial structurally related to
norfloxacin. Available in both oral and IV formulations, it is reportedly useful in the
treatment of gonorrhea, bacterial enteritis, chronic bronchitis and urinary tract
infections. Fleroxacin has a longer serum half-life (9-12 hours) than other drugs of this
class, such as ciprofloxacin, enoxacin and norfloxacin. | | Chemical Properties | White Needle-Like Crystals | | Originator | Kyorin (Japan) | | Uses | An antibacterial. | | Uses | antibiotic | | Definition | ChEBI: A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-n
gative bacteria. | | Manufacturing Process | 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-
oxoquinoline-3-carboxylic acid hydrochloride:
A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was
added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3-
carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent
evaporated and cooled, the residue was adjusted to pH 1 with aqueous
hydrochloric acid. The cooled mixture was filtered off and the solid
recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-
(4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08
g), melting point 269-271°C (decomp.). | | Brand name | Quinodis | | Therapeutic Function | Antibacterial |
| | Fleroxacin Preparation Products And Raw materials |
|
