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| | 5-Methyluridine Basic information |
| | 5-Methyluridine Chemical Properties |
| Melting point | 183-184 °C(lit.) | | density | 1.576±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Methanol (Slightly, Heated, Sonicated), Water (Sparingly, Sonicated) | | form | powder | | pka | 9.55±0.10(Predicted) | | color | white | | InChI | InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1 | | InChIKey | DWRXFEITVBNRMK-JXOAFFINSA-N | | SMILES | OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](O)[C@@H]1O | | CAS DataBase Reference | 1463-10-1(CAS DataBase Reference) |
| Hazard Codes | T+ | | Risk Statements | 26/27/28 | | Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29349990 |
| | 5-Methyluridine Usage And Synthesis |
| Description | 5-Methyluridine is a pyrimidine nucleoside and methylated form of uridine. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is an endogenous methylated nucleoside found in human fluids. In cells, 5-methyluridine is present in tRNA, formed during its post-transcriptional modification by the methylation of uridine. | | Chemical Properties | White Powder | | Uses | A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.
It enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model. It has been used to characterize the activity of a variety of enzymes, including uridine nucleosidase. | | Definition | ChEBI: Ribothymidine is a methyluridine having a single methyl substituent at the 5-position on the uracil ring. It has a role as a human metabolite, an Escherichia coli metabolite and an antigen. |
| | 5-Methyluridine Preparation Products And Raw materials |
| Raw materials | Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-5-methyl- (9CI)-->Uridine, 5-methyl-5'-O-(triphenylmethyl)--->Uridine, 5-methyl-, 2',3',5'-triacetate-->Uridine, 5-methyl-, 2',3',5'-tribenzoate-->2'-O-[2-[(diMethylaMino)oxy]ethyl]-5-Methyl-uridine-->beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate-->1,2,3,5-TETRA-O-ACETYL-BETA-L-RIBOFURANOSE-->N3-Methyl-5-methyluridine-->BIS(O-TRIMETHYLSILYL)THYMINE-->Triethylamine trihydrofluoride-->Thymine-->Guanosine | | Preparation Products | THYMINE-BETA-D-ARABINOFURANOSIDE-->Ethyl benzoate-->Stavudine |
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