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| | Amino-PEG10-alcohol Basic information |
| Product Name: | Amino-PEG10-alcohol | | Synonyms: | Amino-PEG10-alcohol;H2N-PEG10-OH;3,6,9,12,15,18,21,24,27-Nonaoxanonacosan-1-ol, 29-amino-;Amino-PEG10-OH;H2N-PEG10-OH/3,6,9,12,15,18,21,24,27-Nonaoxanonacosan-1-ol, 29-amino-;NH2-PEG10-alcohol | | CAS: | 129449-09-8 | | MF: | C20H43NO10 | | MW: | 457.56 | | EINECS: | | | Product Categories: | | | Mol File: | 129449-09-8.mol |  |
| | Amino-PEG10-alcohol Chemical Properties |
| Boiling point | 533.3±45.0 °C(Predicted) | | density | 1.096±0.06 g/cm3(Predicted) | | pka | 14.36±0.10(Predicted) |
| | Amino-PEG10-alcohol Usage And Synthesis |
| Description | Amino-PEG10-alcohol is a highly water soluble PEG reagent. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | | Biological Activity | Amino-PEG10-OH is a non-cleavable 10-unit PEG-ADC linker for antibody drug-drug (ADC) synthesis. It is also a PEG-based PROTAC linker that can be used for PROTAC synthesis. | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | | target | | Non-cleavable < span> | PEGs | |
| | Amino-PEG10-alcohol Preparation Products And Raw materials |
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