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AG 825

AG 825 Basic information
Product Name:AG 825
Synonyms:TYRPHOSTIN AG 825;TYRPHOSTIN C15;AG 825;5-[(BENZTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYLIDENECYANOACETAMIDE;5-[(BENZOTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYL-IDENECYANOACETAMIDE;4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE;3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano- 2-Propenamide;Tyrphostin C15, 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide
CAS:149092-50-2
MF:C19H15N3O3S2
MW:397.47
EINECS:
Product Categories:Protein Kinase
Mol File:149092-50-2.mol
AG 825 Structure
AG 825 Chemical Properties
storage temp. −20°C
solubility DMSO: soluble
form Yellow solid
Sensitive Light Sensitive
Safety Information
Safety Statements 22-24/25
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
AG 825 Usage And Synthesis
UsesA selective ErbB2 inhibitor
UsesAG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer.
DefinitionChEBI: An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth factor receptor antagonist.
Biological ActivitySelective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
storageStore at +4°C
AG 825 Preparation Products And Raw materials
Canertinib TYRPHOSTIN A25 H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH METHYL 2,5-DIHYDROXYCINNAMATE LAVENDUSTIN A AG 18 DAPH AG 1478 HYDROCHLORIDE CIVENTICHEM CV-409 AG 213 TYRPHOSTIN A51 PD168393 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol AG 825 AG 99 AKOS BBS-00008114 4-METHYL-2-[(METHYLTHIO)METHYL]PHENOL
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