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| Product Name: | P-5091 | | Synonyms: | 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone;P5091, >=98%;CS-726;P5091; P-005091; P 005091; P 5091; P-5091;1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone;Ethanone, 1-[5-[(2,3-dichlorophenyl)thio]-4-nitro-2-thienyl]-;1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone P005091;P005091(P5091) | | CAS: | 882257-11-6 | | MF: | C12H7Cl2NO3S2 | | MW: | 348.22 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 882257-11-6.mol |  |
| | P-5091 Chemical Properties |
| Boiling point | 452.4±45.0 °C(Predicted) | | density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | form | powder | | color | light yellow to dark yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | P-5091 Usage And Synthesis |
| Description | P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable | | Uses | P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47. | | Uses | P5091 has been used:
- as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
- as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
- as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow?resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)
| | Biochem/physiol Actions | P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis. | | References | 1) Chauhan et al. (2012), A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance; Cancer Cell, 22 345
2) Weinstock et al. (2012), Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47; ACS Med. Chem. Lett., 3 789 |
| | P-5091 Preparation Products And Raw materials |
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