2-Chlorothiophene

2-Chlorothiophene Basic information

Product Name:	2-Chlorothiophene
Synonyms:	ChloroThiophene;2-Chlorothiophene,97%;2-Chlorothiphene;2 - chloride thiophene;2-Chlorothiophene, 98+%;2-Chlorothiophene, 98+% 25ML;2-CHLOROTHIOPHENE;2-THIENYL CHLORIDE
CAS:	96-43-5
MF:	C4H3ClS
MW:	118.58
EINECS:	202-505-3
Product Categories:	12;Thiophene&Benzothiophene;Thiophenes;CHIRAL CHEMICALS;Heterocycle-oher series
Mol File:	96-43-5.mol

2-Chlorothiophene Chemical Properties

Melting point	-71.9 °C
Boiling point	127-129 °C (lit.)
density	1.286 g/mL at 25 °C (lit.)
refractive index	n20/D 1.547(lit.)
Fp	73 °F
storage temp.	2-8°C
solubility	soluble in Chloroform
form	Liquid
color	Clear colorless to light brown
Specific Gravity	1.286
Water Solubility	INSOLUBLE
BRN	104652
Stability:	Volatile
InChIKey	GSFNQBFZFXUTBN-UHFFFAOYSA-N
CAS DataBase Reference	96-43-5(CAS DataBase Reference)
NIST Chemistry Reference	Thiophene, 2-chloro-(96-43-5)
EPA Substance Registry System	Thiophene, 2-chloro- (96-43-5)

Safety Information

Hazard Codes	Xi,F,T
Risk Statements	10-36/37/38-23/24/25-37
Safety Statements	16-26-36-45-38-36/37/39-28B-7/9
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS	XM8575000
Hazard Note	Irritant
TSCA	T
HazardClass	3
PackingGroup	II
HS Code	29349990

MSDS Information

Provider	Language
2-Chlorothiophene	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Chlorothiophene Usage And Synthesis

Chemical Properties	Colorless to light yellow liquid
Uses	2-Chlorothiophene was used in the preparation of 5-phenylthiophene derivative.
Application	2-Chlorothiophene is a heterocyclic compound that belongs to the group of organic compounds called thiophenes. It is an effective analgesic and anti-inflammatory drug that has been used in the treatment of inflammatory bowel disease. 2-Chlorothiophene is used as a reagent in chemical synthesis, especially the preparation of pharmaceutical preparations. This compound can be prepared by photoelectron or hydrochloric acid. The suzuki coupling reaction with pyrimidine compounds is another method for synthesizing this compound.
General Description	The photodissociation dynamics of 2-chlorothiophene was studied using resonance enhanced multiphoton ionization (REMPI) time-of-flight (TOF) technique.
Purification Methods	Purify it by fractional distillation at atmospheric pressure or by gas chromatography. [Conde et al. Synthesis 412 1976, Beilstein 17/1 V 303.]

2-Chlorothiophene Preparation Products And Raw materials

Raw materials

2,4-dichlorothiophene-->Thiophene(SIV) (9CI)-->2-Chloro-5-iodothiophene-->3,4-Dichlorothiophene

Preparation Products

(+/-)-4-AMINO-3-(5-CHLORO-2-THIENYL)-BUTANOIC ACID-->5-Chlorothiophene-2-sulfonamide-->4-AMINO-5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER-->5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID-->5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID-->2-CHLORO-3-NITROTHIOPHENE-->5-CHLORO-4-NITROTHIOPHENE-2-SULFONYL CHLORIDE-->2-Chloro-5-chloromethylthiophene-->5-Chlorothiophene-2-sulfonyl chloride-->2-Chloro-5-thiophenecarboxaldehyde-->2-ACETYL-5-CHLOROTHIOPHENE-->5-Methylthiophene-2-carboxaldehyde-->3,6-DIMETHYLOCTANE-->THIENO[2,3-B]THIOPHENE-->ETHYL 2-CHLOROTHIOPHENE-5-GLYOXYLATE

Methylene Chloride 3-Acetyl-2,5-dichlorothiophene 2,5-DICHLOROTHIOPHENE 2-Chlorothiophene Sodium chloride 2,5-Dichloro-3-methylthiophene 3-BROMO-2,5-DICHLOROTHIOPHENE Thiophene Choline chloride Ammonium chloride 2-ACETYL-5-CHLOROTHIOPHENE Mepiquat chloride Thifensulfuron methyl Polyvinyl chloride Tetrahydrothiophene Cephalothin sodium 4-BROMO-2-CHLOROTHIOPHENE TETRACHLOROTHIOPHENE

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