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| | VU 0364439 Basic information |
| Product Name: | VU 0364439 | | Synonyms: | VU 0364439;2-PyridinecarboxaMide, N-[3-chloro-4-[[(2-chlorophenyl)aMino]sulfonyl]phenyl]-;VU0364439/VU-0364439;N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide;N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide VU0364439;CS-629;VU 0364439, >=98%;VU 0364439;VU0364439; VU-0364439 | | CAS: | 1246086-78-1 | | MF: | C18H13Cl2N3O3S | | MW: | 422.29 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1246086-78-1.mol |  |
| | VU 0364439 Chemical Properties |
| density | 1.538±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥21.11 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O | | form | solid | | pka | 7.71±0.10(Predicted) |
| | VU 0364439 Usage And Synthesis |
| Uses | VU 0364439 is a mGlu4 positive allosteric modulator (PAM) (1,2). | | references | [1]. lucyna pomierny-chamioło, kinga rup, bartosz pomierny, et al. metabotropic glutamatergic receptors and their ligands in drug addiction. pharmacology & therapeutics, 2014, 142:281-305.
[2]. albert j. robichaud, darren w. engers, craig w. lindsley, et al. recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as cns therapeutics. acs chemical neuroscience, 2011, 2:433-449.
[3]. colleen m. niswender, kari a. johnson, c. david weaver, et al. discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. mol. pharmacol., 2008, 74(5):1345-1358.
[4]. darren w. engers, patrick r. gentry, richard williams, et al. synthesis and sar of novel, 4-(phenylsulfamoyl)phenylacetamide mglu4 positive allosteric modulators (pams) identified by functional high-throughput screening (hts). bioorg. med. chem. lett., 2010, 20:5175-5178. |
| | VU 0364439 Preparation Products And Raw materials |
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