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N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Basic information
Product Name:N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Synonyms:N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide;N,4-Dimethyl-N-(4-nitrophenyl)-1-piperazineacetamide;Nidanib Impurity 12: N-methyl-2- (4-methylpiperazin-1-yl) -N- (4-nitrophenyl) -acetamide;N-Methyl-2-(4-methyl-1-piperazinyl)-N-(4-nitrophenyl)acetamide;Nintedanib impurity 2/N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide;Nintedanib Intermediate 1;Intedanib Impurity 12;Nintedanib-003
CAS:1139453-98-7
MF:C14H20N4O3
MW:292.33
EINECS:
Product Categories:Intermediate of BIBF-1120 and PKI587
Mol File:1139453-98-7.mol
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Structure
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Chemical Properties
Melting point 94 - 96°C
Boiling point 446.9±40.0 °C(Predicted)
density 1.230
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka7.43±0.10(Predicted)
form Solid
color Pale Yellow to Light Yellow
Safety Information
MSDS Information
N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Usage And Synthesis
UsesN-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide is used as a reactant in the synthetic preparation of 6-methoxycarbonyl-substituted indolinones, such as Intedanib (I666650), which is a triple angiokinase inhibitor and antitumor agent.
Nintedanib Ethanesulfonate Salt 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate 1-Chloro-4-(trimethoxymethyl)benzene 4-methyl-N-(4-nitrophenyl)-1-Piperazineacetamide 1-chloro-2-(trimethoxymethyl)benzene Nintedanib Impurity 76 (Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Methyl oxindole-5-carboxylate 2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide N-(4-aMinophenyl)-2-chloro-N-MethylacetaMide 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide Methyl 1-acetyl-2-oxoindoline-6-carboxylate BIBF-1120 (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
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