(R)-1-Boc-3-hydroxypyrrolidine

(R)-1-Boc-3-hydroxypyrrolidine Basic information

Product Name:	(R)-1-Boc-3-hydroxypyrrolidine
Synonyms:	BOC-(R)-3-HYDROXYPYRROLIDINE;(3R)-(-)-N-BOC-3-HYDROXYPYRROLIDINE;1-PYRROLIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3R)-;(R)-1-N-BOC-3-Hhydroxypyrrolidine;R-1-N-Boc-3- hydroxy-pyrroline;(3R)-3-Hydroxypyrrolidine, N-BOC protected;(R)-(-)-N-BOC-3-pyrrolidinol,98%;3-(R)-Hydroxy-pyrrolidine-1-carboxylicacidtert-butylester
CAS:	109431-87-0
MF:	C9H17NO3
MW:	187.24
EINECS:
Product Categories:	Chiral Building Blocks;Simple Alcohols (Chiral);pharmacetical;Benzenes;Synthetic Organic Chemistry;Chiral chemicals
Mol File:	109431-87-0.mol

(R)-1-Boc-3-hydroxypyrrolidine Chemical Properties

Melting point	62-65 °C(lit.)
alpha	-7 º (c=1, MeOH)
Boiling point	273.3±33.0 °C(Predicted)
density	1.142±0.06 g/cm3(Predicted)
refractive index	-27 ° (C=1, MeOH)
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	14.74±0.20(Predicted)
form	Powder
color	White to off-white
optical activity	[α]20/D 26±1, c = 1 in methanol
InChIKey	APCBTRDHCDOPNY-SSDOTTSWSA-N
CAS DataBase Reference	109431-87-0(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

(R)-1-Boc-3-hydroxypyrrolidine Usage And Synthesis

Chemical Properties	White to off-white powder
Uses	Used in synthesis of ligands for the nicotinic acetylcholine receptor.

(R)-1-Boc-3-hydroxypyrrolidine Preparation Products And Raw materials

Raw materials	1-Pyrrolidinecarboxylic acid, 3-(acetyloxy)-, 1,1-dimethylethyl ester, (3R)--->N-Benzyl-(3S)-hydroxysuccinimide-->N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol-->(S)-1-Boc-3-methanesulfonyloxy-pyrrolidine-->(R)-(-)-3-Pyrrolidinol hydrochloride-->N-Boc-3-pyrrolidinone
Preparation Products	ethyl 2-chloro-4-ethoxy-nicotinate-->Triethylamine hydrochloride-->(R)-TERT-BUTYL 3-(2-METHOXYETHOXY) PYRROLIDINE-1-CARBOXYLATE-->(S)-tert-butyl 3-bromopyrrolidine-1-carboxylate

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