|
| | 4-IODOBUTYL ACETATE Basic information |
| | 4-IODOBUTYL ACETATE Chemical Properties |
| Boiling point | 94-95 °C5.5 mm Hg(lit.) | | density | 1.61 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.497(lit.) | | Fp | 195 °F | | solubility | Difficult to mix. | | form | liquid | | color | Light green turbid | | Sensitive | Light Sensitive | | CAS DataBase Reference | 40596-44-9(CAS DataBase Reference) |
| | 4-IODOBUTYL ACETATE Usage And Synthesis |
| Chemical Properties | CLEAR DARK BROWN LIQUID | | Uses | 4-Iodobutyl acetate is used in the preparation of tricyclohexyl(acetoxybutyl))phosphonium iodide, tri-n-hexyl(acetoxybutyl))phosphonium iodide | | Synthesis Reference(s) | Synthetic Communications, 24, p. 951, 1994 DOI: 10.1080/00397919408020770 | | Synthesis | The synthesis of 4-IODOBUTYL ACETATE is as follows:Acetic acid (0.30mmol, 1.0 equivalent), CuI (0.03mmol, 10.0mol%, 5.7mg) and NaI (0.60mmol, 2.0 equivalent, 89.9mg) were added to a 10mL Schlenk tube equipped with a magnetic stirring device. Vacuum the flask with a pump and backfill it three times with nitrogen. Then, 1.0 mL tetrahydrofuran (12.30 mmol, 41.0 equivalence, 1 mL, c=0.30 M), deionized water (0.45 mmol, 1.5 equivalence) and TMSCF3 (0.36 mmol, 1.2 equivalence) were added under N2 atmosphere. The mixture is stirred at 150°C (thermostatic oil bath pot) for 12 hours. After cooling to room temperature, dilute the mixture with ethyl acetate (15 mL), wash with water and brine, and dry on anhydrousNa2SO4. After Extraction by EtOAc (5 mL x 3), the combined organic layer was dehydrated with anhydrousNa2SO4 and concentrated under reduced pressure. The crude product is purified by rapid chromatography on silica gel to obtain alkyl iodide.
 |
| | 4-IODOBUTYL ACETATE Preparation Products And Raw materials |
|
