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| | L-Glutathione Basic information |
| Product Name: | L-Glutathione | | Synonyms: | NOV-002;White lyophilizate;L-Glutathione oxidized Vetec(TM) reagent grade, >=98%;Glutathione(Oxidized Form), free acid;n-(n-gamma-glutamyl-cysteinyl)glycine-(2,2)-disulfide;N,N’-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-,L-Glutamine;n’-(dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-l-glutamin;oxidizedglutathione | | CAS: | 27025-41-8 | | MF: | C20H32N6O12S2 | | MW: | 612.63 | | EINECS: | 248-170-7 | | Product Categories: | Amino Acids & Derivatives;Sulfur & Selenium Compounds | | Mol File: | 27025-41-8.mol |  |
| | L-Glutathione Chemical Properties |
| Melting point | 178 °C (dec.)(lit.) | | alpha | -99 º (c=4, water) | | density | 1.3688 (rough estimate) | | refractive index | -105 ° (C=2, H2O) | | storage temp. | 2-8°C | | solubility | H2O: soluble | | form | powder | | pka | 2.12, 3.59, 8.75, 9.65(at 25℃) | | color | White to off-white | | Water Solubility | soluble | | Merck | 13,4488 | | BRN | 1718700 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChIKey | YPZRWBKMTBYPTK-USZNOCQGSA-N | | CAS DataBase Reference | 27025-41-8(CAS DataBase Reference) | | EPA Substance Registry System | Oxiglutatione (27025-41-8) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25-36/37/39-27-37/39 | | WGK Germany | 2 | | RTECS | MC0556500 | | HS Code | 29309090 | | Toxicity | mouse,LD50,intravenous,> 2gm/kg (2000mg/kg),Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. |
| | L-Glutathione Usage And Synthesis |
| Description | L-Glutathione oxidized is produced by the oxidation of glutathione.
Detoxification of reactive oxygen species is accompanied by production
of it. It can be used for the
research of sickle cells and erythrocytes. | | Chemical Properties | White lyophilized powder | | Uses | L(-)-Glutathione is a biomarker for fatty liver disease.
| | Uses | S,S'-Ethylenebis(glutathione) is a haloethane-glutathione conjugate formed via GSH transferases. S,S'-Ethylenebis(glutathione) formation is used to study the polymorphism in glutathione conjugation ac
tivity of human erythrocytes towards ethylene dibromide. | | Uses | L-Glutathione is used as a Acts as hydrogen acceptor in enzymatic determination of NADP and NADPH, it is used to reduced back to glutathione (GSH) via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress | | Definition | ChEBI: Glutathione disulfide is an organic disulfide and a glutathione derivative. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a glutathione disulfide(2-). | | Application | L-Glutathione (GSH) has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses. May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose. | | Biochem/physiol Actions | L-Glutathione, oxidized is frequently measure in vivo as an indicator of oxidative stress. Oxidized L-Glutathione may be converted to L-glutathione by various reducing systems. | | Purification Methods | Purify it by recrystallisation from 50% aqueous EtOH. Its solubility in H2O is 5%. Store it at 4o. [Li et al. J Am Chem Soc 76 225 1954, Berse et al. Can J Chem 37 1733 1959, Beilstein 4 IV 3168.] |
| | L-Glutathione Preparation Products And Raw materials |
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