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Homatropine Hydrobromide

Homatropine Hydrobromide Basic information
Product Name:Homatropine Hydrobromide
Synonyms:alpha-hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide;MANDELYTROPINE HYDROBROMIDE;(+/-)-HOMATROPINE HYDROBROMIDE;HOMATROPINE HYDROBROMIDE;DL-HOMATROPINE HYDROBROMIDE;(+-)-homatropinebromide;1-alpha-h,5-alpha-h-tropan-3-alpha-ol,mandelate(ester),hydrobromide;Tropine mandelate hydrobromide, DL-endo-α-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide
CAS:51-56-9
MF:C16H22BrNO3
MW:356.25
EINECS:200-105-3
Product Categories:Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;ISOPTO;Miscellaneous Natural Products;Alkaloids;Biochemistry;Tropane Alkaloids
Mol File:51-56-9.mol
Homatropine Hydrobromide Structure
Homatropine Hydrobromide Chemical Properties
Melting point 214-217 °C
storage temp. 2-8°C
solubility Freely soluble in water, sparingly soluble in alcohol.
form neat
color White to Off-White
Water Solubility soluble
Merck 14,4730
CAS DataBase Reference51-56-9(CAS DataBase Reference)
EPA Substance Registry SystemHomatropine hydrobromide (51-56-9)
Safety Information
Hazard Codes T
Risk Statements 23/24/25
Safety Statements 45-24/25-22
RIDADR 1544
WGK Germany 3
RTECS YM5602000
HazardClass 6.1
PackingGroup III
HS Code 29399900
Homatropine Hydrobromide Usage And Synthesis
DescriptionHomatropine is an anticholinergic agent. It reduces acetylcholine-induced contractions of isolated goat detrusor muscle strips when used at a concentration of 5 μM. Homatropine (1 μM) inhibits acetylcholine- or methacholine-induced contraction of isolated rat anococcygeus muscle. It inhibits serotonin- or thrombin-induced platelet aggregation in isolated sheep platelet-rich plasma (IC50s = 4.3 and 100 μM, respectively). Topical ophthalmic administration of homatropine induces partial mydriasis in Angora goats.
Chemical Propertieswhite crystals or crystalline powder
Usesanticholinergic (opthalmic)
UsesHomatropine is an anticholinergic agent. Homatropine acts as an inhibitor of the muscarinic acetylcholine receptors. Homatropine is used in eye drops as a cycloplegic and as a mydriatic, to dilate the pupil.
Brand nameIsopto Homatropine (Alcon) .
General DescriptionHomatropine hydrobromide,1 H,5 H-tropan-3 -ol mandelate (ester) hydrobromide(Homatrocel), occurs as white crystals or as awhite, crystalline powder that is affected by light. It is solublein water (1:6) and alcohol (1:40), less soluble in chloroform(1:420), and insoluble in ether.
Solutions are incompatible with alkaline substances,which precipitate the free base, and with the commonreagents that precipitate alkaloids. As with atropine, solutionsare sterilized best by filtration through a bacteriologicalfilter.
Clinical UseHomatropine hydrobromide is used topically to paralyzethe ciliary structure of the eye (cycloplegia) and to effectmydriasis. It behaves very much like atropine but is weakerand less toxic. In the eye, it acts more rapidly but less persistentlythan atropine. Dilation of the pupil takes place inabout 15 to 20 minutes, and the action subsides in about24 hours. By using a miotic, such as physostigmine, it ispossible to restore the pupil to normality in a few hours.
Homatropine Hydrobromide Preparation Products And Raw materials
Serotonin hydrochloride Tetracaine hydrochloride N-Acetyl-L-cysteine 4-Aminobenzoic acid Pilocarpine nitrate Dichloroacetic acid Dacarbazine Cisatracurium besylate Bromoacetyl bromide Scopolamine Homatropine Hydrobromide Atropine Tropine (+)-HOMATROPINE METHYLBROMIDE Flutropium bromide tropenziline bromide HOMATROPINE HOMATROPINE METHYL BROMIDE
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