| Chemical Properties | yellow-brown crystals or powder |
| Uses | 4-Nitroquinoline N-Oxide is used in method for constructing animal model of oral mucosal malignancy related to Kras mutation. |
| Uses | 4-Nitroquinoline N-oxide has been used as a model compound to study its carcinogenic effects. |
| Definition | ChEBI: A quinoline N-oxide carrying a nitro substituent at position 4. |
| General Description | Yellowish-brown plates or needles or yellow solid. |
| Air & Water Reactions | 4-NITROQUINOLINE N-OXIDE is hygroscopic and light sensitive. Insoluble in water. |
| Reactivity Profile | 4-NITROQUINOLINE N-OXIDE reacts with strong oxidizing agents. |
| Health Hazard | ACUTE/CHRONIC HAZARDS: 4-NITROQUINOLINE N-OXIDE may cause irritation. When heated to decomposition it may emit toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. |
| Fire Hazard | Flash point data for 4-NITROQUINOLINE N-OXIDE are not available; however, 4-NITROQUINOLINE N-OXIDE is probably combustible. |
| Biochem/physiol Actions | Skin and lung tumor initiator under experimental conditions. |
| Safety Profile | Suspected carcinogen
with experimental carcinogenic, neoplas tigenic,
and tumorigenic data. Poison by
intraperitoneal and subcutaneous routes. An experimental teratogen. Other experimental
reproductive effects. Human mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx. |
| Purification Methods | The N-oxide recrystallises from aqueous acetone as yellow needles or platelets. [Ochiai J Org Chem 18 534 1953, Seki et al. J Phys Chem 91 126 1987, Beilstein 20 III/IV 3396.] |
