|
| | Nifuratel Basic information |
| Product Name: | Nifuratel | | Synonyms: | 5-[(Methylsulfanyl)Methyl]-4-[(E)-[(5-nitrofuran-2-yl)Methylidene]aMino]-1,3-oxazolidin-2-one;3-[(5-Nitro-2-furfurylidene)aMino]-5-[(Methylthio)Methyl]-2-oxazolidinone;5-(MethylMercaptoMethyl)-3-(5-nitro-2-furfurylidenaMino)-2-oxazolidinone;2-Oxazolidinone,5-[(Methylthio)Methyl]-3-[[(5-nitro-2-furanyl)Methylene]aMino]-;5-[(METHYLTHIO)METHYL]-3-[[(5-NITRO-2-FURANYL)METHYLENE]AMINO-]-2-OXAZO-LIDINONE;5-methylthiomethyl-3-(5-nitrofurfurylideneamino)-2-oxazolidone;NIFURATEL;5-((methylthio)methyl)-3-((5-nitrofurfurylidine)amino)-2-oxazolidinon | | CAS: | 4936-47-4 | | MF: | C10H11N3O5S | | MW: | 285.28 | | EINECS: | 225-576-2 | | Product Categories: | Pharmaceuticals;APIS;API;Intermediates & Fine Chemicals | | Mol File: | 4936-47-4.mol |  |
| | Nifuratel Chemical Properties |
| Melting point | 176-178°C | | Boiling point | 423.6±53.0 °C(Predicted) | | density | 1.57±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Acetone (Sparingly), DMSO (Slightly) | | form | Solid | | pka | -2.49±0.40(Predicted) | | color | Yellow | | Stability: | Hygroscopic | | CAS DataBase Reference | 4936-47-4(CAS DataBase Reference) |
| Risk Statements | 68 | | Safety Statements | 36/37 | | HS Code | 29321900 | | Toxicity | LD50 oral in mouse: > 4500mg/kg |
| | Nifuratel Usage And Synthesis |
| Description | Nifuratel is a derivative of nitrofuran , it is a broad spectrum antibiotic with broad-spectrum antimicrobial effect, Nystatin is a polyene antifungal,it has strong effects on trichomoniasis, bacteria, Candida albicans , it plays a strong killing role especially in common pathogens for gynecological infections such as gram-positive and gram-negative bacteria, trichomoniasis, mold, chlamydia and mycoplasma. | | Chemical Properties | Bright Yellow Powder.
It is poorly soluble in water, but readily soluble in dimethylformamide. | | Originator | Macmiror,Poli,Italy,1965 | | Uses | Nifuratel is a drug used as an antibacterial, antifungal, antiprotozoal (Trichomonas).
Nifuratel has a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections from Candida spp. | | Definition | ChEBI: Nifuratel is a member of furans and a C-nitro compound. | | Brand name | Macmiror (Polichimica Sap, Italy); Magmilor
(Polichimica Sap, Italy); Polmiror (Polichimica Sap,
Italy); Tydantil (Polichimica Sap, Italy). | | Clinical Use | Nifuratel indications include:
1.bacterial vaginosis, trichomonas vaginitis, vulvovaginal candidiasis, vaginal mixed infections.
2.urinary tract infections.
3.gastrointestinal amoebiasis and trichomoniasis Jia. | | Synthesis | The synthesis of Nifuratel is as follows:Add 450ml of ethanol, 450ml of water, and 50ml of phosphoric acid into the reaction flask, then add 5-nitrofuraldehyde diacetate 267.5 (1.1mol), reflux for 0.5-1h, and naturally cool to room temperature to obtain a 5-nitrofurfural solution. Under dark conditions, add N-amino-5-methylthiomethyl-2-oxazolidinone dropwise to the 5-nitrofurfural solution, stir and react at room temperature for 2 to 3 hours, stand still for crystallization, filter and filtered cake was washed with absolute ethanol solvent (60ml×3) and dried to obtain crude nifuratel. Under dark conditions, take the crude Nifuratel and add 10 times the volume of glacial acetic acid, heat to boil, add activated carbon, filter while hot, the filtrate is allowed to stand for crystallization and filtration, the filter cake is washed with ethanol (60ml×3), nifuratel pure product (197.7g, yield 99.93%, purity 99.93%).
 |
| | Nifuratel Preparation Products And Raw materials |
|
