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| | DEMETHOXYCURCUMIN Basic information |
| Product Name: | DEMETHOXYCURCUMIN | | Synonyms: | Feruloyl-P-hydroxycinnnamoylmethane;MonodeMethoxycurcuMin;(1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-Methoxyphenyl)-1,6-heptadiene-3,5-d;(E,E)-1-(4-Hydroxy-3-Methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione;1-(4-Hydroxy-3-Methoxyphenyl)-7-(p-hydroxyphenyl)-1,6-heptadiene-3,5-dione;DeMethoxyCurcuMin(DesMethoxycurcuMin);p-HydroxycinnaMoylferuloylMethane;Demethoxycurcumin | | CAS: | 22608-11-3 | | MF: | C20H18O5 | | MW: | 338.35 | | EINECS: | | | Product Categories: | Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 22608-11-3.mol |  |
| | DEMETHOXYCURCUMIN Chemical Properties |
| Melting point | 166～170℃ | | Boiling point | 571.4±50.0 °C(Predicted) | | density | 1.282±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | pka | 8.31±0.46(Predicted) | | color | orange | | LogP | 3.113 (est) |
| Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 2 | | HS Code | 29145090 |
| | DEMETHOXYCURCUMIN Usage And Synthesis |
| Uses | The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do
wn-regulation of the transcriptional coactivator p300. | | Uses | Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS. | | Definition | ChEBI: Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, a beta-diketone, an enone and a diarylheptanoid. | | General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | | Biochem/physiol Actions | Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB. |
| | DEMETHOXYCURCUMIN Preparation Products And Raw materials |
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