Molnupiravir

Molnupiravir Basic information
Product Name:Molnupiravir
Synonyms:Uridine, 4-oxime, 5'-(2-methylpropanoate), (4Z)-;Molnupiravir-001-QA;Molnupiravir D7Q: What is Molnupiravir D7 Q: What is the CAS Number of Molnupiravir D7;MolnupiravirQ: What is Molnupiravir Q: What is the CAS Number of Molnupiravir Q: What is the storage condition of Molnupiravir;((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate;Molnupiravir;Molnupiravir In-House;((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (Molnupiravir Impurity)
CAS:2492423-29-5
MF:C13H19N3O7
MW:329.31
EINECS:
Product Categories:
Mol File:2492423-29-5.mol
Molnupiravir Structure
Molnupiravir Chemical Properties
density 1.62±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)
pka6.71±0.20(Predicted)
Safety Information
MSDS Information
Molnupiravir Usage And Synthesis
DescriptionProdrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection.
DefinitionChEBI: Molnupiravir is a nucleoside analogue that is N(4)-hydroxycytidine in which the 5'-hydroxy group is replaced by a (2-methylpropanoyl)oxy group. It is the prodrug of the active antiviral ribonucleoside analog N(4)-hydroxycytidine (EIDD-1931), has activity against a number of RNA viruses including SARS-CoV-2, MERS-CoV, and seasonal and pandemic influenza viruses. It is currently in phase III trials for the treatment of patients with COVID-19. It has a role as a prodrug, an anticoronaviral agent and an antiviral drug. It is a nucleoside analogue, an isopropyl ester and a ketoxime. It is functionally related to a N(4)-hydroxycytidine.
Biological ActivityMolnupiravir is a broad-spectrum antiviral prodrug of the nucleoside analog β-D-N4-hydroxycytidine (NHC). It competes predominantly with CTP for incorporation; it induces lethal viral mutagenesis by increasing G to A and C to U transition mutations without inhibition of RNA synthesis in replicating coronaviruses, which prevents the development of viral resistance. In primary airway epithelial cell cultures, Molnupiravir dose-dependently inhibits SARS-CoV-2 infectious virus production; it also inhibits MERS-CoV and SARS-CoV with EC50 values in the submicromolar range. In mice infected with SARS-CoV or MERS-CoV, it improves pulmonary function, and reduces virus titer and body weight loss. Molnupiravir also displays in vivo efficacy against seasonal and pandemic influenza A shed virus. It is orally bioavailable.
storageStore at -20°C
Molnupiravir Preparation Products And Raw materials
N(4)-hydroxycytidine 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one 2',3'-O-isopropylidene cytidine 6-HYDROXYLAMINOURACIL 2,4(1H,3H)-Pyrimidinedione, 1-β-L-ribofuranosyl-, 4-oxime (9CI) Uridine, 4-oxime, 5'-(2-methylpropanoate), (4E)- Uridine, 5'-(2-methylpropanoate) (9CI) ((2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl)methyl isobutyrate

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.