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| | METHYL ISOCYANOACETATE Basic information |
| | METHYL ISOCYANOACETATE Chemical Properties |
| Boiling point | 75-76 °C10 mm Hg(lit.) | | density | 1.09 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.417(lit.) | | Fp | 193 °F | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | form | Liquid | | color | Clear yellow to brown | | Water Solubility | Miscible with organic solvents. Slightly miscible with water. | | BRN | 3537963 | | CAS DataBase Reference | 39687-95-1(CAS DataBase Reference) |
| | METHYL ISOCYANOACETATE Usage And Synthesis |
| Chemical Properties | CLEAR YELLOW TO BROWN LIQUID | | Uses | Methyl isocyanoacetate is used in the copper-catalyzed, diastereoselective synthesis of oxazolines. It is involved in the direct aldol reaction with carbonyl compounds to prepare corresponding oxazoline by using catechol-copper network catalyst. Further, it is also involved in four-component Ugi condensation reaction. It undergoes asymmetric aldol reaction with fluorinated benzaldehyde using gold(I) as a catalyst. | | Uses | Methyl isocyanoacetate has been used in the copper-catalyzed, diastereoselective synthesis of oxazolines. | | General Description | Methyl isocyanoacetate undergoes direct aldol reaction with carbonyl compounds in the presence of solid-phase catechol-copper network catalyst to yield corresponding oxazolines. It also participates in four-component Ugi condensation reaction. |
| | METHYL ISOCYANOACETATE Preparation Products And Raw materials |
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