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| | 2',7'-DICHLOROFLUORESCEIN Basic information |
| | 2',7'-DICHLOROFLUORESCEIN Chemical Properties |
| Melting point | 280 °C (dec.)(lit.) | | Boiling point | 514.77°C (rough estimate) | | density | 0.79 g/mL at 20 °C | | refractive index | 1.5300 (estimate) | | Fp | 12°C (53.6°F) | | storage temp. | room temp | | solubility | alcohol: passes test | | pka | 4.46(at 25℃) | | form | crystalline | | color | orange to red-brown, powder | | PH Range | 4.0 (colorless) - 6.6 (green) | | Water Solubility | Soluble in ethanol and methanol. Slightly dimethyl sulfoxide. Insoluble in water. | | λmax | 509nm | | BRN | 58009 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | Major Application | Electroluminescent devices, sol-gel silica films, integrated circuits, photoresists, lithographic
printing plates, recording material, LED devices, photoconductors, Solid-state dye laser, lithographic printing plates, inks, Fluorescent pH sensors, emissive probes, chemotherapeutic treatment of disease, phototherapeutic treatment of disease, photodynamic treatment of disease | | InChIKey | NZVMJBGGAQSNLI-UHFFFAOYSA-N | | CAS DataBase Reference | 76-54-0(CAS DataBase Reference) | | EPA Substance Registry System | Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',7'-dichloro-3',6'-dihydroxy- (76-54-0) |
| Hazard Codes | Xi,F | | Risk Statements | 36/37/38-36-67-11 | | Safety Statements | 26-36-16 | | RIDADR | UN 1219 3/PG 2 | | WGK Germany | 3 | | RTECS | NT8050000 | | TSCA | Yes | | HS Code | 3204 19 00 |
| | 2',7'-DICHLOROFLUORESCEIN Usage And Synthesis |
| Chemical Properties | red to yellow solid | | Uses | Widely used probe, e.g. for determination of carbohydrates by fluorescence densitometry after TLC and determination of H2O2 by chemiluminescence. Fluorescent additives used in indirect fluorimetric detection in OTC-HPLC. | | Uses | 2',7'-Dichlorofluorescein is used as an indicator and as a cellular antioxidant activity. It is also used for the determination of carbohydrates and hydrogen peroxide by fluorescence densitometry and chemiluminescence respectively. It is used as an indicator for argentometry by Fajans method. It is also involved in the cellular antioxidant activity assay. It is utilized as an additive in fluorescence and laser studies.
A new fluorescent sensor for Cd2+ and its application in living cells imaging. Tetrahedron Lett. 2015, 56 (11), 1322-1327.
Colorimetric and fluorogenic signaling of fluoride ions by thiophosphinated dichlorofluorescein. Dyes Pigm. 2015, 112, 170-175. | | Uses | 2',7'-Dichlorofluorescein is used as an indicator and as a cellular antioxidant activity. It is also used for the determination of carbohydrates and hydrogen peroxide by fluorescence densitometry and chemiluminescence respectively. It is used as an indicator for argentometry by Fajans method. It is also involved in the cellular antioxidant activity assay. It is utilized as an additive in fluorescence and laser studies. | | Definition | 2',7'-dichlorofluorescein is a member of 2-benzofurans. It has a role as a fluorochrome. It derives from a fluorescin. | | Application | 2',7'-dichlorofluorescein has been used as an oxidation-sensitive fluorescent probe to measure ROS (reactive oxygen species) formation in cells. | | Biological Activity | 2',7'-dichlorofluorescein is an oxidation-sensitive fluorescent probe. 2′7′-dichlorofluorescein diacetate is oxidized to 2′7′-dichlorofluorescein in the presence of ROS (reactive oxygen species). | | Biochem/physiol Actions | 2′,7′-Dichlorofluorescein is an oxidation-sensitive fluorescent probe. 2′7′-dichlorofluorescein diacetate is oxidized to 2′7′-dichlorofluorescein in the presence of ROS (reactive oxygen species). |
| | 2',7'-DICHLOROFLUORESCEIN Preparation Products And Raw materials |
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