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| Product Name: | ZPCK | | Synonyms: | SL-01;carbamicacid,[3-chloro-2-oxo-1-(phenylmethyl)propyl]-,phenylmethylester,(s;(S)-benzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate;N-CBZ-L-PHENYLALANINE CHLOROMETHYL*KETON E;z-l-phe chloromethyl ketone;(S)-Penzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate.;ZPCK, N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone;(3S)-1-Chloro-3-(benzyloxycarbonylamino)-4-phenyl-2-butanone | | CAS: | 26049-94-5 | | MF: | C18H18ClNO3 | | MW: | 331.79 | | EINECS: | 247-432-8 | | Product Categories: | | | Mol File: | 26049-94-5.mol |  |
| Melting point | 107-108 °C(lit.) | | Boiling point | 503.1±50.0 °C(Predicted) | | density | 1.1630 (rough estimate) | | refractive index | 1.6470 (estimate) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming). | | form | solid | | pka | 10.74±0.46(Predicted) | | color | White | | optical activity | [α]23/D +30°, c = 1 in chloroform | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. | | CAS DataBase Reference | 26049-94-5 | | EPA Substance Registry System | Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-27-36/37/39-45 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | HS Code | 29225000 |
| Description | SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ. | | Chemical Properties | white powder | | Uses | Enzyme inhibitor. | | Uses | SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth. | | Uses | ZPCK's a peptidase from baker's yeast,and it is with esterase activities of carboxypeptidase Y.
| | References | 1) Li et al. (2011), A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction; J. Biomol. Screening, 16 450 |
| | ZPCK Preparation Products And Raw materials |
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