Eflornithine hydrochloride

Eflornithine hydrochloride Basic information
Product Name:Eflornithine hydrochloride
Synonyms:RMI-71782;RMI-71782 HYDROCHLORIDE;2-(difluoromethyl)-dl-ornithinehydrochloridehydrate;alpha-difluoromethylornithinehydrochloridehydrate;dl-ornithine,2-(difluoromethyl)-,monohydrochloride,hydrate;DFMO;DFMO HCL;DFMO HYDROCHLORIDE
CAS:68278-23-9
MF:C6H13ClF2N2O2
MW:218.63
EINECS:269-532-0
Product Categories:Amino Acids and Derivatives;facial hair remover
Mol File:68278-23-9.mol
Eflornithine hydrochloride Structure
Eflornithine hydrochloride Chemical Properties
Melting point 181-184°C
storage temp. Store at -20°C
solubility H2O: >10 mg/mL, soluble
form solid
color white
Water Solubility Soluble to 75 mM in water
CAS DataBase Reference68278-23-9(CAS DataBase Reference)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
Eflornithine hydrochloride Usage And Synthesis
UsesAntineoplastic; antiprotozoal.
UsesDL-alpha-Difluoromethylornithine Hydrochloride is an irreversible inhibitor of ornithine decarboxylase.
IndicationsVaniqa (eflornithine hydrochloride 13.9%) cream is a unique topical cream that slows anagen hair growth by irreversibly blocking the enzyme ornithine decarboxylase. This enzyme produces polyamines in the hair matrix that are partially responsible for the growth of the anagen hair. The cream was tested only on the upper lip and chin region. The onset of action is usually within 8 weeks of starting the b.i.d. treatment, and the hair growth will return to baseline within 8 weeks of discontinuing the drug. Patients need to be reminded that this product does not remove hair but slows its growth in between whatever they use for hair removal.
Brand nameOrnidyl (Sanofi Aventis); Vaniqa (Skinmedica).
storageDesiccate at RT
Eflornithine hydrochloride Preparation Products And Raw materials
Eflornithine hydrochloride Levofloxacin HCL Capsule DFMO BETA-FLUORO-DL-ALANINE DFMO EFLORNITHINE L-Ornithine ORNITHINE HC Topotecan hydrochloride 2,5-DIAMINO-2-METHYL-PENTANOIC ACID HCL L(+)-Ornithine hydrochloride DFMO Fluoxetine hydrochloride 2-FLUORO-1,1-DIMETHYL-ETHYLAMINE HCL-SALT 2-(Difluoromethyl)-DL-ornithine 1-AdaMantanethylaMine DFMO-PCV protocol (S)-2-AMINO-2-METHYLBUTYRIC ACID 2-(Difluoromethyl)ornithine hydrate hydrochloride, DFMO hydrate hydrochloride,DFMO

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