N-Cbz-L-Leucine

N-Cbz-L-Leucine Basic information

Product Name:	N-Cbz-L-Leucine
Synonyms:	N-Benzyloxycarbonyl-L-leucine, 98+%;Z-L-LEUCINE extrapure;N-Carbobenzyloxy-L-leucine, N-Cbz-L-leucine, Z-L-Leucine;L-(Carbobenzyloxy)leucine;L-Leucine, N-[(phenylmethoxy)carbonyl]-;L-N-(Benzyloxycarbonyl)leucine;N-Carboxy-L-leucine N-benzyl ester;(2S)-2-(Benzyloxycarbonylamino)-4-methylpentanoic acid
CAS:	2018-66-8
MF:	C14H19NO4
MW:	265.3
EINECS:	217-960-3
Product Categories:	Amino Acids;Amino Acids (N-Protected);Amino Acid Derivatives;Biochemistry;Cbz-Amino Acids;Z-Amino acid series;Leucine [Leu, L];Z-Amino Acids and Derivatives
Mol File:	2018-66-8.mol

N-Cbz-L-Leucine Chemical Properties

alpha	-17 º (c=2, ethanol)
Boiling point	408.52°C (rough estimate)
density	1 g/mL at 25 °C(lit.)
refractive index	n20/D 1.512(lit.)
Fp	85 °F
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	4.00±0.21(Predicted)
form	viscous liquid
color	Colorless to Light yellow
Specific Gravity	1.0
optical activity	[α]20/D 17°, c = 2 in ethanol
Water Solubility	Not miscible or difficult to mix in water. Soluble in chloroform, DMSO and methanol.
BRN	1253861
CAS DataBase Reference	2018-66-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	10-20/22-37/38-40-41-36/37/38-20/21/22-67-63-19
Safety Statements	16-26-36/37/39-45-36-36/37-60
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS	OH2921000
HS Code	29242990

MSDS Information

Provider	Language
Z-Leu-OH	English
SigmaAldrich	English
ACROS	English
ALFA	English

N-Cbz-L-Leucine Usage And Synthesis

Chemical Properties	yellow oil or weak solid
Uses	Reactant for: Peptide-based preparation of potential antitumor agents Preparation of cyclopropyl peptidomimetics Peptide synthesis
Definition	ChEBI: A L-leucine derivative obtained by the substitution of a benzyloxycarbonyl group on the nitrogen atom.

N-Cbz-L-Leucine Preparation Products And Raw materials

Raw materials

L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-leucyl- (9CI)-->L-Leucine,N-[(phenylmethoxy)carbonyl]-, 2-phenylhydrazide-->L-Leucine, N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester-->CARBOBENZYLOXYLEUCYLLEUCINAMIDE-->N-Cbz-D-Leucine-->L-Alaninamide-->Methyl L-leucinate hydrochloride-->Benzyl-4,6-dimethyl-pyrimidine-2-thio formate-->Z-LEU-OH DCHA-->Z-LEU-PHE-NH2-->H-PHE-NH2-->Z-LEU-OME-->N-(Benzyloxycarbonyloxy)succinimide

Preparation Products

Z-LEU-ONP-->CALPEPTIN

CBZ-L-LEUCINE DCHA,N-ALPHA-CBZ-L-LEUCINE DICYCLOHEXYLAMMONIUM SALT,CBZ-L-LEUCINE DICYCLOHEXYLAMINE SALT N-Cbz-L-Leucine LABOTEST-BB LT00847694 Z-BETA-TBU-ALA-OH DCHA Z-LEU-OSU DDZ-LEU-OH CHA N-Carbobenzyloxyglycine CBZ-L-LEUCINE N-CARBOXYANHYDRIDE BOC-GLY-LEU-OH (S)-N-CBZ-4-PIPERIDYLALANINE METHYL ESTER N-(F17 CBZ) L-LEUCINE BIS(CARBOBENZOXY-L-LEUCINE)PIPERAZINE SALT (R)-CBZ-1-AMINO-2,2-DIMETHYLCYCLOPROPANECARBOXYLIC ACID L-Leucine CBZ-L-LEUCINE METHYL ESTER N-CBZ-DL-Leucine N-Carbobenzyloxy-DL-leucine,N-CBZ-DL-LEUCINE tert-Butyl carbazate L-tert-Leucine

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