|
| | HOOCCH2CH2O-PEG10-CH2CH2COOH Basic information |
| Product Name: | HOOCCH2CH2O-PEG10-CH2CH2COOH | | Synonyms: | HOOCCH2CH2O-PEG10-CH2CH2COOH;HOOCCH2CH2-PEG10-CH2CH2COOH;4,7,10,13,16,19,22,25,28,31,34-Undecaoxaheptatriacontanedioic acid;Di-Acid-PEG11;HOOCCH2CH2O-PEG10-CH2CH2COOH/4,7,10,13,16,19,22,25,28,31,34-undecaoxaheptatriacontane-1,37-dioic acid | | CAS: | 2097010-30-3 | | MF: | C26H50O15 | | MW: | 602.67 | | EINECS: | | | Product Categories: | peg | | Mol File: | 2097010-30-3.mol |  |
| | HOOCCH2CH2O-PEG10-CH2CH2COOH Chemical Properties |
| Boiling point | 684.6±55.0 °C(Predicted) | | density | 1.165±0.06 g/cm3(Predicted) | | pka | 3.97±0.10(Predicted) |
| | HOOCCH2CH2O-PEG10-CH2CH2COOH Usage And Synthesis |
| Biological Activity | Bis-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | HOOCCH2CH2O-PEG10-CH2CH2COOH Preparation Products And Raw materials |
|
