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Rilmenidine

Rilmenidine Basic information
Product Name:Rilmenidine
Synonyms:n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine;oxaminozoline;RILMENIDINE;1,1-dicyclopropyl-n-(2-oxazolinyl)-methylamin;2-((dicyclopropylmethyl)imino)-oxazolidin;2-((dicyclopropylmethyl)imino)oxazolidine;2-(dicyclopropylmethylamino)-2-oxazoline;4,5-dihydro-n-(dicyclopropylmethyl)-2-oxazolamin
CAS:54187-04-1
MF:C10H16N2O
MW:180.25
EINECS:259-021-0
Product Categories:Antihypertensive;Imidazoline binding site
Mol File:54187-04-1.mol
Rilmenidine Structure
Rilmenidine Chemical Properties
Melting point 106-107°
Boiling point 355.5±9.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility H2O: 7.3 mg/mL
pka7.88±0.50(Predicted)
form solid
color white
CAS DataBase Reference54187-04-1(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
RTECS RP7207400
MSDS Information
ProviderLanguage
Oxaminozoline English
Rilmenidine Usage And Synthesis
DescriptionRilmenidine is a new antihypertensive agent with a selective alphaz-agonist/antagonist profile, reportedly useful in the management of mild to moderate hypertension. Its fmt-line indication is possible because of the clear dissociation of its antihypertensive activity from other neurophannacological effects.
Chemical Propertieswater soluble
OriginatorServier (France)
UsesI1-imidazoline binding site ligand and a2-adrenoceptor agonist, exhibits higher I1 vs. a2 selectivity than clonidine
DefinitionChEBI: Rilmenidine is an isourea.
Brand nameHyperium
Biological ActivityI 1 -imidazoline binding site selective ligand and α 2 -adrenoceptor agonist. Possesses greater I 1 vs α 2 selectivity than the prototypical compound, clonidine.
Metabolic pathwayIn short-term rat hepatocyte cultures, oxaminozoline is metabolized and its four metabolites resulting from oxidation or hydrolysis are identified, three of which are identical to those reported in vivo. The presence of an additional minor metabolite in culture may be due to the higher metabolic rate of oxaminozoline in this model system.
Rilmenidine Preparation Products And Raw materials
Raw materialsThionyl chloride-->Monoethanolamine-->Phenyl chloroformate-->2-Chloroethyl isocyanate
Chloromethyl isopropyl carbonate (S)-1-CYCLOPROPYLETHYLAMINE Rilmenidine 5-Methyl-1H-benzotriazole Cyclopropyl methyl ketone 3-Methyl-2-butanone Tolyltriazole RILMENIDINE DIHYDROGEN PHOSPHATE,rilmenidine phosphate DICYCLOPROPYLMETHANE N,N-Diisopropylethylamine 1-CYCLOPROPYL-ETHYLAMINE RILMENIDINE HEMIFUMARATE SALT O-METHYLISOUREA ACETATE CHEMBRDG-BB 4003538 (R)-1-(Cyclopropylethyl)amine Allylamine Dicyclopropane methylamine Dihydromyrcenol
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