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| | Phenetidine Basic information |
| | Phenetidine Chemical Properties |
| Melting point | 2-5 °C(lit.) | | Boiling point | 250 °C(lit.) | | density | 1.065 g/mL at 25 °C(lit.) | | vapor pressure | 2.93Pa at 25℃ | | refractive index | n20/D 1.559(lit.) | | Fp | 240 °F | | storage temp. | 2-8°C | | solubility | 20g/l | | pka | 5.2(at 28℃) | | form | A liquid | | color | Clear Yellow | | PH | 8 (1g/l, H2O, 20℃) | | Water Solubility | practically insoluble | | Sensitive | Air Sensitive | | Merck | 14,7228 | | BRN | 606666 | | Stability: | Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents. | | InChIKey | IMPPGHMHELILKG-UHFFFAOYSA-N | | CAS DataBase Reference | 156-43-4(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Ethoxyaniline(156-43-4) | | EPA Substance Registry System | p-Phenetidine (156-43-4) |
| Hazard Codes | T,Xi,Xn | | Risk Statements | 23/24/25-33-68-43-36-20/21/22 | | Safety Statements | 28-36/37-45-46 | | RIDADR | UN 2311 6.1/PG 3 | | WGK Germany | 1 | | RTECS | SI6465500 | | F | 8-10 | | Hazard Note | Irritant | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29222200 | | Toxicity | LD50 orl-rat: 580 mg/kg GISAAA 35(8),28,70 |
| | Phenetidine Usage And Synthesis |
| Chemical Properties | colourless liquid | | Uses | A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils. | | Definition | ChEBI: An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin. | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 27, p. 347, 1984 DOI: 10.1021/jm00369a019 | | General Description | Colorless to dark red liquid. | | Air & Water Reactions | Very sensitive to exposure to air and light. Turns red to brown on exposure to light and air. . Slightly soluble in water. | | Reactivity Profile | Phenetidine reacts vigorously with powerful oxidizers. | | Fire Hazard | Phenetidine is combustible. | | Safety Profile | Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. |
| | Phenetidine Preparation Products And Raw materials |
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