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| | trans-1,2-Cyclohexanedicarboxylic acid Basic information |
| Product Name: | trans-1,2-Cyclohexanedicarboxylic acid | | Synonyms: | trans-Cyclohexane-1,2-dicarboxylic acid for synthesis;TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID;TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID, 95%, REMAINDER CIS;rel-(1R*)-1β*,2α*-Cyclohexanedicarboxylic acid;rel-(1R*,2R*)-1,2-Cyclohexanedicarboxylic acid;rel-Cyclohexane-1β*,2α*-dicarboxylic acid;trans-1,2-Cyclohexanedicarboxylic acid, remainder cis, 95%;TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACDI | | CAS: | 2305-32-0 | | MF: | C8H12O4 | | MW: | 172.18 | | EINECS: | 218-975-8 | | Product Categories: | Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts | | Mol File: | 2305-32-0.mol |  |
| | trans-1,2-Cyclohexanedicarboxylic acid Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | GU9065000 | | TSCA | Yes | | HS Code | 29172000 |
| | trans-1,2-Cyclohexanedicarboxylic acid Usage And Synthesis |
| Chemical Properties | white crystalline powder | | Uses | trans-1,2-cyclohexanedicarboxylic acid be used as organic intermediates. | | Uses | trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain. | | Purification Methods | It is purified by recrystallisation from EtOH or H2O. It is formed by hydrolyzing the anhydride with water. The dimethyl ester has m 95-96o (from *C6H6/pet ether). [Abell J Org Chem 22 769 1957, Smith & Byrne J Am Chem Soc 72 4406 1950, Linstead et al. J Am Chem Soc 64 2093 1942, Beilstein 9 III 3812, 9 IV 2801.] The 1R,2R-(-)-trans-cyclohexane-1,2-acid [46022-05-3] has m 171-182o and [ ] D -20o (c 1, Me2CO). cis-Cyclohexane-1,2-dicarboxylic anhydride (cis-hexahydrophthalic anhydride) [85-42-7, 13149-00-3] M 154.2, m 32-34o, b 158o/17mm. It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.] |
| | trans-1,2-Cyclohexanedicarboxylic acid Preparation Products And Raw materials |
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