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| | 4-METHOXYPYRIDAZINE Basic information |
| Product Name: | 4-METHOXYPYRIDAZINE | | Synonyms: | 4-METHOXYPYRIDAZINE;4-Methoxy-pyridazin;4-methoxypyridazine hydrochloride;Pyridazine, 4-methoxy-;4-METHOXYPYRIDAZINE ISO 9001：2015 REACH | | CAS: | 20733-11-3 | | MF: | C5H6N2O | | MW: | 110.11 | | EINECS: | | | Product Categories: | | | Mol File: | 20733-11-3.mol |  |
| | 4-METHOXYPYRIDAZINE Chemical Properties |
| Melting point | 43-44℃ | | Boiling point | 244℃ | | density | 1.102 | | Fp | 89℃ | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.28±0.10(Predicted) |
| | 4-METHOXYPYRIDAZINE Usage And Synthesis |
| Uses | 4-methoxypyridazine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Uses | 
To a solution of 3 ,6-dichloro-4- methoxypyridazine (30 g, 167.59 mmol, 1.00 equiv) and ammonium formate (3 1 g, 491.63 mmol, 2.93 equiv) in MeOH (500 mL) was added 10% palladium on carbon (3 g) catalyst. The mixture was stirred under 1 atmosphere of at rt overnight. The catalyst was removed by filtration and the filtrate was concentrated under vacuum. The residue was triturated in 500 mL of DCM MeOH ( 10: 1 ) and the solid material was filtered out. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (2:1 to 1: 1) to give 1 5 g (81%) of 4-methoxypyridazine as a brown oil. TLC: petroleum ether: ethyl acetate=2: 1 , Rf=0.1 . |
| | 4-METHOXYPYRIDAZINE Preparation Products And Raw materials |
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