|
| | BMS-986205 Basic information |
| Product Name: | BMS-986205 | | Synonyms: | BMS-986205;Linrodostat;LINRODOSTAT;BMS 986205;BMS986205;BMS 986205;BMS986205;BMS-986205(Linrodostat);CS-2743;(2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamid;Cyclohexaneacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-α-methyl-, cis-(αR)- | | CAS: | 1923833-60-6 | | MF: | C24H24ClFN2O | | MW: | 410.91 | | EINECS: | | | Product Categories: | API | | Mol File: | 1923833-60-6.mol |  |
| | BMS-986205 Chemical Properties |
| Boiling point | 606.8±45.0 °C(Predicted) | | density | 1?+-.0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM) | | pka | 13.80±0.70(Predicted) |
| | BMS-986205 Usage And Synthesis |
| Biological Activity | Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays. | | Description | BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. | | Uses | BMS-986205 is a compound being studied for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders. |
| | BMS-986205 Preparation Products And Raw materials |
|
