1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine
1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine Basic information
Product Name: 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine Synonyms: Vonoprazan-015 ;TAK438 Impurity 8 ;Vonoprazan impurity 19/1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine ;Vonoprazan Impurity 65 ;Vonoprazan-21 ;Vonola fumarate in favor of product impurity P ;5-(2-Fluorophenyl)-N-methyl-1H-pyrrole-3-methanamine ;1-[5-(2-Fluorophenyl)-1H-pyrrol-3-yl]-N-methylmethylamine CAS: 1610043-62-3 MF: C12H13FN2 MW: 204.24 EINECS: Product Categories: Mol File: 1610043-62-3.mol
1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine Chemical Properties
Boiling point 326.5±32.0 °C(Predicted) density 1.141±0.06 g/cm3(Predicted) solubility DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) form Sticky Solid to Solid pka 16.60±0.50(Predicted) color Pale Yellow to Brown Stability: Hygroscopic
1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine Usage And Synthesis
Uses 5-(2-Fluorophenyl)-N-methyl-1H-pyrrole-3-methanamine is an impurity of Vonoprazan a novel potassium-?competitive acid blocker for the treatment of acid-?related diseases.
1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine Preparation Products And Raw materials
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-
1-methylpyridin-1-ium-4-sulfonate (1R,3aR,7aR)-1-((2R,5S,E)-5,6-dimethyl-6-
((trimethylsilyl)oxy)hept-3-en-2-yl)-7a-
methyloctahydro-4H-inden-4-one
tert-butyl(((1R,3aR,7aR)-1-((2R,5S,E)-5,6-dimethyl
-6-((tetrahydro-2H-pyran-2-yl)oxy)hept-3-en-2-yl)
-7a-methyloctahydro-1H-inden-4-yl)oxy)dimethylsilane benzyl (4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)
carbamate
(1R,3aR,7aR)-1-((2R,5S,E)-6-hydroxy-5,6-diMethylhept-3-en-2-yl)-7a-Methylhexahydro-1H-inden-4(2H)-one (1R,3aR,7aR)-1-((2R,5S,Z)-6-hydroxy-5,6-dimethylhept
-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-one
5-chloropyridine-3-sulfonyl chloride 1H-Inden-4-ol, octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-triMethyl-2-hexen-1-yl]-7a-Methyl-, (1R,3aR,4S,7aR)-
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde PL-A':(1R,3aR,7aR)-1-((2R,5R,E)-6-hydroxy-5,6-dimethy
lhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-one
PL-AS':(1R,3aR,7aR)-1-((2R,5R,Z)-6-hydroxy-5,6-dimeth
ylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-one
Vonoprazan Fumarate impurity (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,Z)-6-hydroxy-
5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-
inden-4-ylidene)ethylidene)cyclohexane-1,3-diol
PYRIDINE-4-SULFONYL CHLORIDE 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 2-[[(3aR,4S,6R,6aS)-6-[7-Chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-ethanol
(3S,6R,E)-6-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis
((tert-butyldimethylsilyl)oxy)cyclohexylidene)
ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-
2,3-dimethylhept-4-en-2-ol
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