ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards (alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile

(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile

(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile Basic information
Product Name:(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile
Synonyms:(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile;Entacapone impurity H;Entacapone Impurity 24(Entacapone EP Impurity H);(E)-3-(3,4-dihydroxy-5-nitrophenyl)-2-(piperidine-1-carbonyl)prop-2-enenitrile;Entacapone Impurity 8（Entacapone EP Impurity H）;(2E)-3-(3,4-Dihydroxy-5-nitrophenyl;1-Piperidinepropanenitrile, α-[(3,4-dihydroxy-5-nitrophenyl)methylene]-β-oxo-, (αE)-;-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β
CAS:1150310-15-8
MF:C15H15N3O5
MW:317.3
EINECS:
Product Categories:
Mol File:1150310-15-8.mol
(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile Structure
(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile Chemical Properties
Melting point 207-208℃ (ethanol )
Safety Information
MSDS Information
(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile Usage And Synthesis
Uses(αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile Preparation Products And Raw materials
3,4-Dihydroxy-5-Nitrobenzoic Acid (E/Z)-3-O-Methyl Entacapone Entacapone EP IMpurity B (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide Entacapone 4-β-D-Glucuronide 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N,N-diethyl-, (2E)- TYRPHOSTIN AG 1290 Entacapone Impurity 13 Entacapone 3-b-D-Glucuronide 3,5-DINITROCATECHOL 6-Methoxy-2,4-dinitrophenol Entacapone (E)-3-O-Methyl Entacapone CIS-ENTACAPONE 3-Nitro-4,5-dihydroxybenzaldehyde Entacapone EP IMpurity I Entacapone Impurity 4 Entacapone Impurity 10
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