(3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one

(3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one Basic information
Product Name:(3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one
Synonyms:(3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one;(R)-3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-1-one;Rasagiline Related Compound HCl;1H-Inden-1-one, 2,3-dihydro-3-(2-propyn-1-ylamino)-, (3R)-;Rasagiline Impurity 14;3-Keto-N-Propargyl-1-Aminoindan;(3R)-3-(Prop-2-yn-1-ylamino)indan-1-one (3-Ketorasagiline);Rasagiline Impurity 10 Mesylate
CAS:1312077-05-6
MF:C12H11NO
MW:185.22
EINECS:
Product Categories:Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:1312077-05-6.mol
(3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one Structure
(3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one Chemical Properties
Melting point 51-54°C
storage temp. Refrigerator
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
color Light Beige to Beige
Safety Information
MSDS Information
(3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one Usage And Synthesis
Uses(3R)-2,3-Dihydro-3-(2-propyn-1-ylamino)-1H-inden-1-one, is a building block in the preparation of Rasagiline (R126000), which is a selective irreversible MAO-B inhibitor. Rasagiline is also an Antiparkinsonian agent.
(3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one Preparation Products And Raw materials
3-(1-methyl-1H-indole-3-carbonyl)hexanedioic acid 1-Methyl-1H-indole-3-carboxylic acid 1-Methylindole Ramosetron hydrochloride Rasagiline Dimer Impurity Rasagiline Impurity 5 Mesylate 5-(1-methyl-1H-indole-3-carbonyl)-1H-benzo[d]imidazol-2(3H)-one Rasagiline Rasagiline Impurity 2 ramosetron 4,5,6,7-Tetrahydro-1H-benzoiMidazole-5-carboxylic acid hydrochloride Rasagiline Impurity 3 Rasagiline Dipropynyl HCl 3a,7a-dihydroxy-5-(1-methyl-1H-indole-3-carbonyl)-hexahydro-1H-benzo[d]imidazol-2(3H)-one Ramosetron Impurity 13 Rasagiline Impurity 7 Mesylate Rasagiline Impurity 4 Rasagiline Impurity 1 HCl

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