| Description | Iron, which is the chief constituent of Earth’s core, is the most abundant element in Earth as a whole (about 35 percent) .
Ferric pyrophosphate is an iron replacement product, is a mixed-ligand iron complex in which iron (III) is bound to pyrophosphate and citrate.
It is widely used to fortify cereal flours and infant cereals, dispersible ferric pyrophosphate is as well absorbed as ferrous sulfate in adults.
pyrophosphate ions participate in the ion transfer processes. These ions, as chelating agents, would release iron from transferrin and form a ferric pyrophosphate complex, and that pyrophosphate alone has the ability to mediate iron exchange from transferring to ferritin.
Ferric pyrophosphate citrate should only be added to the bicarbonate concentrate; do not add to acid concentrate mixtures.
Ferric pyrophosphate citrate is not intended for use in patients receiving peritoneal dialysis; it has not been studied in patients receiving home hemodialysis. |
| Chemical Properties | Ferric pyrophosphate (iron(III)pyrophosphate, Fe4(P207)3*xH2O) is a tan or yellowish-white odorless powder or Soluble crystals. It is insoluble in water but is soluble in mineral acids. It is prepared by reacting sodium pyrophosphate with ferric citrate.
Ferric pyrophosphate is an important kind of compounds insoluble in water and also poorly soluble in dilute acid. It does not modify organoleptic characteristics of foods because of its white colour and low reactivity, making it suitable for many difficult-to-fortify food vehicles, such as salt, cereals, infant formulas, and rice. It has been demonstrated to be an effective iron fortificant from efficacy studies. However, the poor solubility of ferric pyrophosphate in gastric juice limits its bioavailability, which furthemore reduces its nutritional value. The relative bioavailability value (RBV) of ferric pyrophosphate was reported to be only about 50% from human studies. |
| Uses | Iron(III) Pyrophosphate can be used as an iron supplement for people with iron deficiencies. |
| Uses | Food and Feed additives/Food additives |
| Uses | Ferric Pyrophosphate is a nutrient supplement, tan or yellowish
white in color, prepared by reacting sodium pyrophosphate with
ferric citrate. the ingredient may be used in infant formula. it is also
termed iron (iii) pyrophosphate. |
| Preparation | Ferric pyrophosphate was prepared by adding sodium pyrophosphate solution to ferric chloride solution.
2Fe2(SO4)3+3Na4P2O7=Fe4(P2O7)3+6Na2SO4
The precipitate collected was washed and a ferric pyrophosphate suspension was dispersed with lecithin and other emulsifiers. |
| Definition | ChEBI: Ferric pyrophosphate is an iron coordination entity composed from Fe(3+) cations and diphosphate(4-) anions in a 4:3 ratio. It contains a diphosphate(4-). |
| General Description | Ferric Phosphate is a tan or yellowish white odorless powder. It is insoluble in water and soluble in mineral acids. It can be prepared by reacting sodium pyrophosphate with ferric citrate. It shows good bioaccesibility. |
| Flammability and Explosibility | Nonflammable |
| Safety Profile | When heated to
decomposition it emits very toxic fumes of POx. |
