N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Basic information
Product Name:N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
Synonyms:2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazol-6-amine;BNKY007-PZ02;2H-indazole-6-aMine,N-(2-chloro -4-pyrimidinyl)-N,2,3-trimethyl-;Pazopanib Impurity 22;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine;N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-
CAS:444731-75-3
MF:C14H14ClN5
MW:287.75
EINECS:810-050-2
Product Categories:
Mol File:444731-75-3.mol
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Structure
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Chemical Properties
Melting point 167-173℃
Boiling point 524.4±35.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
pka2.82±0.30(Predicted)
Stability:Hygroscopic
CAS DataBase Reference444731-75-3
Safety Information
MSDS Information
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Usage And Synthesis
UsesN-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Preparation Products And Raw materials
Raw materials2H-Indazol-6-amine, N,2,3-trimethyl--->N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine-->2,4-Dichloropyrimidine-->Iodomethane
4(1H)-Pyrimidinone, 2-chloro- (9CI) N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Pazopanib Related Compound 2 Pazopanib Impurity 9 (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid 4-Acetoxy-3-acetoxymethylacetophenone 1,3-DiMethyl-6-aMino-1H-indazole 2,3-dimethyl-2H-indazol-6-amine hydrochloride 3-Methyl-6-nitro-2H-indazole Pazopanib Related Compound 3 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide Pazopanib-d6 5-BROMO-3-METHYLINDOLE 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE 1,3-Dimethyl-6-nitro-1H-indazole Pazopanib

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