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| | Perindoprilat Basic information |
| Product Name: | Perindoprilat | | Synonyms: | PERINDOPRILAT;PERINDOPRILAT HYDRATE;(2s-(1(r*(r*)),2-alpha,3a-beta,7a-beta))-);1h-indole-2-carboxylicacid,octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl;(2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-Carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid;(2S,3aS,7aS)-1-[(S)-2-[[(S)-1-Carboxybutyl]amino]-1-oxopropyl]hexahydroindoline-2-carboxylic acid;S-9780;Perindoprilat ,95% | | CAS: | 95153-31-4 | | MF: | C17H28N2O5 | | MW: | 340.41 | | EINECS: | | | Product Categories: | Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles | | Mol File: | 95153-31-4.mol |  |
| | Perindoprilat Chemical Properties |
| Melting point | 153-155°C | | Boiling point | 568.1±45.0 °C(Predicted) | | density | 1.222±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 2.27±0.20(Predicted) | | form | Solid | | color | White to Pale Beige | | Stability: | Hygroscopic | | CAS DataBase Reference | 95153-31-4 |
| | Perindoprilat Usage And Synthesis |
| Chemical Properties | White to Off-White Solid | | Uses | An angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive. | | Uses | Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension. Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.[Cayman Chemical] | | Uses | Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive. | | Definition | ChEBI: Perindoprilat is a dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a drug metabolite. It is an organic heterobicyclic compound, a dipeptide, a dicarboxylic acid and a L-alanine derivative. |
| | Perindoprilat Preparation Products And Raw materials |
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