ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid

4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid

4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Basic information
Product Name:4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid
Synonyms:4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid;p-[(2-Amino-4-hydroxy-6-pteridinyl)methyl(methyl)amino]benzoic acid;N10-Methyl Pteroic Acid;4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoic Acid;Metfol-B;NSC 408937;4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino}benzoic acid;Methotrexate EP Impurity D
CAS:5623-18-7
MF:C15H14N6O3
MW:326.31
EINECS:
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:5623-18-7.mol
4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Structure
4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Chemical Properties
Melting point >245°C (dec.)
Boiling point 583.7±60.0 °C(Predicted)
density 1.58±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Aqueous Base (Slightly), DMSO (Very Slightly, Heated), Methanol (Very Slightly)
pka4.74±0.10(Predicted)
form neat
color Orange to Red
Safety Information
MSDS Information
4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Usage And Synthesis
Chemical PropertiesDark Orange Solid
UsesN10-Methyl Pteroic Acid (Methotrexate EP Impurity D) is a Methotrexate (M260675) impurity D.
UsesMethotrexate (M260675) impurity D.
4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid Preparation Products And Raw materials
Raw materials4-(Methylamino)benzoic acid-->6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE-->3,5-DI-T-BUTYL-4-METHOXYBENZALDEHYDE-->4-Aminobenzoic acid
METHOTREXATE-D3 4-[N-(2,4-DIAMINO-6-PTERIDINYLMETHYL)-N-METHYLAMINO] BENZOIC ACID 7-HYDROXY METHOTREXATE Methotrexate Folic Acid Related Compound A/Calcium Formyltetrahydrofolate Methotrexate α-Methyl Ester L-Glutamic acid der. METHOTREXATE DIMETHYL ESTER L-Glutamic acid, N-[N-[N-[N-[4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-.gamma.-gluta myl]-L-.gamma.-glutamyl]-L-.gamma.-glutamyl]- 2,4-DIAMINO-6-(HYDROXYMETHYL)PTERIDINE N-(4-(METHYLAMINO)BENZOYL)-L-GLUTAMIC ACID methotrexate-gamma-dimethylamide Methotrexate γ-Methyl Ester Methotrexate Related Compound E (50 mg) (4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid, hemihydrochloride) 4-[Methyl[(2-amino-4-hydroxypteridine)-6-ylmethyl]amino]benzoic acid 4-HYDROXYPTERIDINE N10-(TRIFLUOROACETYL)PTEROIC ACID PTEROIC ACID
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