|
| | Tiapride hydrochloride Basic information |
| Product Name: | Tiapride hydrochloride | | Synonyms: | N-[2-(DIETHYLAMINO)ETHYL]-5-[METHYL-SULFONYL]-O-ANISAMIDE HYDROCHLORIDE;n-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)benzamidehydrochloride;n-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)-benzamidmonohydroch;n-(2-(diethylamino)ethyl)-2-methoxy-5-(methylsulfonyl)-benzamidmonohydrochloride;N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulphonyl)benzamide monohydrochloride;TiapridHCl;Tiapridhydrochlorid;Cuckool | | CAS: | 51012-33-0 | | MF: | C15H25ClN2O4S | | MW: | 364.89 | | EINECS: | 256-908-4 | | Product Categories: | | | Mol File: | 51012-33-0.mol |  |
| | Tiapride hydrochloride Chemical Properties |
| Melting point | approximate 200℃ (dec.) | | storage temp. | 2-8°C | | solubility | Very soluble in water, soluble in methanol, slightly soluble in anhydrous ethanol. | | form | neat | | color | White | | Merck | 14,9421 | | CAS DataBase Reference | 51012-33-0(CAS DataBase Reference) |
| WGK Germany | 2 | | RTECS | CV4203800 | | HS Code | 2930.90.2900 |
| | Tiapride hydrochloride Usage And Synthesis |
| Chemical Properties | White Solid | | Originator | Tiapridal,Delagrange,France,1977 | | Uses | Tiapride is a D2 and D3 dopamine receptor antagonist and a antipsychotic drug predominately used in the pharmacotherapy of patients with dementia. | | Uses | Dopamine antagonist;Antidyskinetic | | Uses | Tiapride hydrochloride is a D2 and D3 dopamine receptor antagonist and a antipsychotic drug predominately used in the pharmacotherapy of patients with dementia.
| | Definition | ChEBI: Tiapride hydrochloride is a member of benzamides. | | Manufacturing Process | 5 g of 2-methoxy-5-methylsulfonylbenzoic acid, 50 ml of dioxan, 3.02 ml of
triethylamine and 3 g of isobutyl chloroformate were introduced into a 250 ml
balloon flask at ambient temperature.
After the mixture had been stirred for 30 minutes, 3 g of N,N_x0002_diethylethylenediamine were added. The reaction mixture was stirred for 6
hours and the solvents were evaporated under vacuum.
The residue was dissolved in 50 ml of water and the solution was made
alkaline with sodium hydroxide. The precipitate formed was filtered, washed
and dried in a drying oven at 60°C. 6 g of N-(diethylaminoethyl)-2-methoxy-
5-methylsulfonylbenzamide (melting point: 124°C to 125°C) was produced. | | Therapeutic Function | Antiemetic |
| | Tiapride hydrochloride Preparation Products And Raw materials |
|
