NU1025

NU1025 Basic information

Product Name:	NU1025
Synonyms:	NU1025;PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem;NU 1025;NU 1025;8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE;8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE;8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE;8-Hydroxy-2-methylquinazoline-4-one ,97%;8-hydroxy-2-methyl-1H-quinazolin-4-one
CAS:	90417-38-2
MF:	C9H8N2O2
MW:	176.17
EINECS:
Product Categories:	All Inhibitors;Inhibitors;Aromatics
Mol File:	90417-38-2.mol

NU1025 Chemical Properties

Melting point	253-258°C
Boiling point	345.4±44.0 °C(Predicted)
density	1.42
storage temp.	−20°C
solubility	DMSO: 35 mg/mL, soluble
pka	8.68±0.20(Predicted)
form	solid
color	off-white
CAS DataBase Reference	90417-38-2

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	26
WGK Germany	3
HS Code	29335990

MSDS Information

Provider	Language
SigmaAldrich	English

NU1025 Usage And Synthesis

Description	NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC₅₀ = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.
Chemical Properties	Off-White to Pale Yellow Solid
Uses	NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical]
Uses	A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
Definition	ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.
Biological Activity	Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.

NU1025 Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Methanol-->Tetrahydrofuran-->N,N-Dimethylformamide-->Thionyl chloride-->Magnesium sulfate-->Ammonia-->Pyridine-->Nitrogen-->Isopropyl alcohol-->Hydrogen-->Acetyl chloride-->Ethyl acetoacetate-->2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE-->Boron tribromide-->3-METHOXY-2-NITROBENZOIC ACID

3-Aminobenzamide 4-AMINO-1,8-NAPHTHALIMIDE TIQ-A 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE ABT-888 LY2409881 DPQ Rucaparib 4-Hydroxyquinazoline 5-Benzoyloxy-1(2H)-isoquinolinone 1(2H)-Isoquinolinone, 5-aMino-, Monohydrochloride 1,5-ISOQUINOLINEDIOL GSK J4 HCl NU1025 2-METHYL-4(3H)-QUINAZOLINONE 8-methoxy-2-methylquinazolin-4(3H)-one 2-METHYL-4(3H)-QUINAZOLINONE Oxazoline

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