N-Methyl-N-(trimethylsilyl)trifluoroacetamide

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Basic information

Product Name:	N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Synonyms:	N-METHYL-N-(TRIMETHYLSILYL)TRIFLUOROACETAMIDE W. 1% TMCS;N-METHYL-N-(TRIMETHYLSILYL)TRIFLUORO-ACE TAMIDE, DERIVATIZATION GRADE;N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACET-A MIDE, FOR GC;N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAM, 10x1ML PACKSIZE;N-METHYL-N-(TRIMETHYLSILYL)TRIFLUOROACETAMIDE 98%;N-Methyl-N-(Trimethylsily)Trifluoroacetamide;N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 98;MSTFA~N-Trimethylsilyl-N-methyltrifluoroacetamide
CAS:	24589-78-4
MF:	C6H12F3NOSi
MW:	199.25
EINECS:	246-331-6
Product Categories:	Silylation Reagents;Amines;Silylation (GC Derivatizing Reagents);Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Si-N Compounds;Trimethylsilylation (GC Derivatizing Reagents);Silylation Reagents;Derivatization Reagents;Derivatization Reagents GC;Reagents for SilylationProtection and Derivatization;Silicon-BasedAnalytical/Chromatography;Protecting and Derivatizing Reagents;Analytical Chemistry;GC Derivatizing Reagents;Si (Classes of Silicon Compounds);Silylacetamides;Reagents for SilylationAnalytical/Chromatography;Amines, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:	24589-78-4.mol

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Chemical Properties

Melting point	98-100°C
Boiling point	130132°C
density	1.075 g/mL at 25 °C(lit.)
vapor density	>1 (vs air)
vapor pressure	8.8 mm Hg ( 27 °C)
refractive index	n20/D 1.383
Fp	77 °F
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	-1.34±0.70(Predicted)
form	Liquid
color	Clear colorless to light yellow
Specific Gravity	1.076
Water Solubility	reacts
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
BRN	1941550
InChIKey	MSPCIZMDDUQPGJ-UHFFFAOYSA-N
CAS DataBase Reference	24589-78-4(CAS DataBase Reference)
EPA Substance Registry System	Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4)

Safety Information

MSDS Information

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Usage And Synthesis

Chemical Properties	Clear colorless to light yellow liquid
Uses	A new metabolite of Famprofazone in humans.
Uses	N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.
Definition	ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.
General Description	N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.
Purification Methods	Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]

N-Methyl-N-(trimethylsilyl)trifluoroacetamide Preparation Products And Raw materials

Raw materials

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