2,5-Dimethyl pyrazine

2,5-Dimethyl pyrazine Basic information
Product Name:2,5-Dimethyl pyrazine
Synonyms:2,5-Dimethylprazin;2,5-Dimethylpyrazine (contains 2,6-isomer);2,5-DIMETHYL PYRAZINE, NATURAL;2,5-Dimethylpyrazine,99%;5-diMethyl pyrazine;2,5-DiMethylpyrazine, 99% 25GR;2,5-DiMethylpyrazine, 99% 5GR;2,5-Dimethylpyrazine, Research grade
CAS:123-32-0
MF:C6H8N2
MW:108.14
EINECS:204-618-3
Product Categories:pyrazine Flavor;Mono- & Polyalkylpyrazines;Acipimox;Building Blocks;Heterocyclic Building Blocks;Pyrazine compounds;Pyrazines;Pyrazine;Heterocyclic Compounds;Alphabetical Listings;C-D;Flavors and Fragrances
Mol File:123-32-0.mol
2,5-Dimethyl pyrazine Structure
2,5-Dimethyl pyrazine Chemical Properties
Melting point 15°C
Boiling point 155 °C (lit.)
density 0.99 g/mL at 25 °C (lit.)
FEMA 3272 | 2,5-DIMETHYLPYRAZINE
refractive index n20/D 1.502(lit.)
Fp 147 °F
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka2.21±0.10(Predicted)
form Liquid
color Clear colorless to pale yellow
Specific Gravity0.990
PH7 (H2O)
Odorat 0.10 % in dipropylene glycol. nutty roasted baked potato
Odor Typechocolate
Sensitive Hygroscopic
JECFA Number766
BRN 107052
LogP0.64
CAS DataBase Reference123-32-0(CAS DataBase Reference)
NIST Chemistry ReferencePyrazine, 2,5-dimethyl-(123-32-0)
EPA Substance Registry SystemPyrazine, 2,5-dimethyl- (123-32-0)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38-R22
Safety Statements 26-36
RIDADR NA 1993 / PGIII
WGK Germany 3
RTECS UQ2800000
Hazard Note Irritant
TSCA Yes
HS Code 29339990
MSDS Information
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2,5-Dimethyl pyrazine English
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2,5-Dimethyl pyrazine Usage And Synthesis
Chemical Propertiesclear colorless to pale yellow liquid
Chemical Properties2,5-Dimethylpyrazine has a characteristic odor of earthy, potato-like odor.
OccurrenceReported to be present in bakery products, roasted barley, cocoa products, roasted coffee, dairy products, pork, peanuts, pecans, filberts, popcorn, potato products, rum and whiskey, soy products; a volatile component in roasted filberts and in potato chips; reportedly identified in the fat of cooked beef; also reported found in toasted off-flavors. Also reported in cheeses, butter, boiled eggs, grilled beef, tea, barley, oats, oatmeal, soybeans, heated beans, kohlrabi, shrimp and mushrooms. Also reported found in coffee, potato chips and shrimp
Uses2,5-Dimethyl pyrazine is used for blending food, nuts and beverage flavors.
Uses2,5-Dimethylpyrazine is used as a reagent in the synthesis of bone-targeted proteasome inhibitors for multiple myeloma (MM). 2,5-Dimethylpyrazine is also used in the preparation of 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340); a degredation product of Clavulanic Acid (C563750) which is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
DefinitionChEBI: 2,5-Dimethylpyrazine is a member of pyrazines.
PreparationBy the interaction of acrolein and ammonia when heated in glycerol in the presence of ammonium salts; by self-condensation of aminoacetone, followed by oxidation with mercury chloride.
Aroma threshold valuesDetection: 80 ppb to 1.8 ppm
Taste threshold valuesTaste characteristics at 7.5 ppm: musty, potato, cocoa and nutty with a fatty and oily nuance
General Description2,5-Dimethylpyrazine is a pyrazine compound that is mainly formed in food products such as cooked rice or roasted peanuts due to the Maillard reaction between sugars and proteins during cooking or roasting process.
Safety ProfileModerately toxic by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx
Purification MethodsPurify it via its picrate (m 150o) which is decomposed with a base (e,g, KOH) and distilled. [Wiggins and Wise J Chem Soc 4780 1956]. [Beilstein 23/5 V 403.]
2,5-Dimethyl pyrazine 2-Methylpyrazine 2,5-Dibromopyrazine DIMETHYL DIHYDROCYCLOPENTAPYRAZINE Dacthal DIMETHYLPYRAZINE N,N-Dimethylformamide ETHANE 2,6-Dimethylpyrazine Dimethyl fumarate Pyrazinamide Sulfachoropyrazine sodium Dimethyl ether Dimethyl carbonate Glipizide 2,3-Diethyl-5-methylpyrazine Dimethyl phthalate Dimethyl sulfate

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