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| | Valethamate bromide Basic information |
| Product Name: | Valethamate bromide | | Synonyms: | S 78;Valeric acid, 3-methyl-2-phenyl-, ester with diethyl(2-hydroxyethyl)methylammonium bromide;Velamate;ethanaminium bromide;N,N-Diethyl-N-methyl-2-((3-methyl-2-phenylpentanoyl);Diethyl-methyl-[2-(3-methyl-2-phenyl-pentanoyl)oxyethyl]azanium bromide;N,N-Diethyl-N-methyl-2-[(3-methyl-1-oxo-2-phenylpentyl)oxy]ethanaminium Bromide
N-[2-(2-Methyl-1-phenylbutylcarbonyloxy)ethyl]diethylmethylammonium Bromide;N,N-Diethyl-N-Methyl-2-((3-Methyl-2-phenylpentanoyl)oxy)ethanaMiniuM broMide | | CAS: | 90-22-2 | | MF: | C19H32BrNO2 | | MW: | 386.37 | | EINECS: | 201-977-8 | | Product Categories: | Ammonium Bromides (Quaternary);Quaternary Ammonium Compounds | | Mol File: | 90-22-2.mol |  |
| | Valethamate bromide Chemical Properties |
| Melting point | 120-127℃ | | RTECS | BP7600000 | | storage temp. | Inert atmosphere,Room Temperature | | solubility | almost transparency[in Water] | | Water Solubility | almost transparency in Water | | solubility | DMSO : 100 mg/mL (258.82 mM; Need ultrasonic) | | form | Powder | | color | White to Almost white | | Merck | 14,9906 | | CAS DataBase Reference | 90-22-2(CAS DataBase Reference) |
| | Valethamate bromide Usage And Synthesis |
| Originator | Murel,Ayerst,US | | Definition | ChEBI: Valethamate bromide is an alkylbenzene. | | Manufacturing Process | Benzyl cyanide is first reacted with 2-butylbromide in the presence of sodium
amide to give 2-phenyl-3-methylvaleronitrile which is hydrolyzed by sulfuric
acid to give 3-methyl-2-phenylpentanoic acid. 24 g of 2-phenyl-3-
methylpentanoic acid are heated for one hour at 175° to 185°C with 30 g of
2-diethylaminoethanol and 0.5 g of sodium methylate. The excess
diethylaminoethanol is removed in vacuo, the residue is dissolved in 300 cc of
2 N-acetic acid, the acid solution is shaken with ether and made alkaline with
concentrated potassium carbonate solution and ice. The ether solution is
washed with water, dried with sodium sulfate and evaporated. The residue is
distilled under high vacuum, yielding 20 to 21 g of the basic ester (60% of the
theoretical) is obtained, the ester boiling at 98° to 100°C at a pressure of
0.03 mm. The hydrochloride of the ester melts at 112°to 113°C and the
methobromide at 100° to 101°C. | | Therapeutic Function | Anticholinergic | | Safety Profile | Poison by ingestion,
subcutaneous, and intravenous routes. See
also ESTERS and BROMIDES. When
heated to decomposition it emits very toxic
fumes of NOx, NH3, and Br-. |
| | Valethamate bromide Preparation Products And Raw materials |
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