(S)-3-Fluoro-pyrrolidine hydrochloride

(S)-3-Fluoro-pyrrolidine hydrochloride Basic information
Product Name:(S)-3-Fluoro-pyrrolidine hydrochloride
Synonyms:(R)-3-FLUORO-PYRROLIDINE HCL;S-(+)-3-Fluoropyrrolidinehydrochloride98%ee;3(S)-fluoropyrrolidine(HCl);(S)-3-Fluoropyrrolidine h...;(S)-(+)-3-Fluoropyrrolidine hydrochloride 97%;(S)-(+)-3-Fluoropyrrolidine hydrochloride≥ 99% (HPLC);(3S)-(+)-3-Fluoropyrrolidine hydrochloride;(S)-3-FLUORO-PYRROLIDINE HCL
CAS:136725-53-6
MF:C4H9ClFN
MW:125.57
EINECS:
Product Categories:Asymmetric Synthesis;Building Blocks;Chemical Synthesis;Chiral Building Blocks;Fluorinated Building Blocks;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Heterocyclic Building Blocks;Pyrrolidines;Chiral Building Blocks
Mol File:136725-53-6.mol
(S)-3-Fluoro-pyrrolidine hydrochloride Structure
(S)-3-Fluoro-pyrrolidine hydrochloride Chemical Properties
Melting point 183-187 °C(lit.)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form Powder or Crystalline Powder
color White to pale brown
optical activity[α]20/D +8°, c = 1% in methanol
InChIKeyLENYOXXELREKGZ-WCCKRBBISA-N
CAS DataBase Reference136725-53-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26
WGK Germany 3
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
(S)-3-Fluoro-pyrrolidine hydrochloride Usage And Synthesis
Chemical PropertiesLight pink to purple solid
UsesThe derived amide acts as an inhibitor of dipeptidyl peptidase IV.1
Uses(S)-(+)-3-Fluoropyrrolidine hydrochloride can be employed as a building block for the preparation of:
  • Fluorinated pyrrolidine derivatives of cyclohexylglycine amides as potential inhibitors for dipeptidyl peptidase IV.
  • Fluoropyrrolidine contaning N--ethylurea pyrazole derivatives as potential and selective inhibitors for Trypanosoma brucei and Trypanosoma cruzi parasitic causative agents.
  • Urea derivatives of (S)-2-(3,4-difluorophenyl)-5-(3-fluoro-N-pyrrolidylamido)benzothiazole as potent antitrypanosomal agents.

Uses(S)-(+)-3-Fluoropyrrolidine, HCl
(S)-3-Fluoro-pyrrolidine hydrochloride Preparation Products And Raw materials
METHYL (3R)-3-AMINO-3-(4-[(4-CHLOROPHENYL)SULFONYL]PHENYL)PROPANOATE D-P-METHYL SULFONE PHENYL ETHYL SERINATE (4R)-4-FLUORO-L-PROLINE HCL 4,4-DIFLUORO-D-PROLINAMIDE HYDROCHLORIDE RARECHEM GT HW 0232 AKOS 92509 METHYL (2S,4R)-4-FLUOROPROLINATE RARECHEM DK HW 0232 AKOS 90052 METHYL (3S)-3-AMINO-3-(4-[(4-CHLOROPHENYL)SULFONYL]PHENYL)PROPANOATE 4-CIS-FLUORO-L-PROLINAMIDE HYDROCHLORIDE 4,4-DIFLUORO-N-METHYL-N-METHOXY-L-PROLINAMIDE HCL RARECHEM AL BL 1413 CHEMPACIFIC 34673 AKOS 92519 AKOS 92774 TRANS-4-FLUORO-N-METHYL-N-METHOXY-L-PROLINAMIDE HCL 3-AMINO-3-(2-CHLORO-4-METHANESULFONYL-PHENYL)-PROPIONIC ACID

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